Abstract：
The relationship between serum albumin (ALB) and short-term prognosis in patients with acute pulmonary embolism (APE) remains unclear. We investigated the predictive value of ALB for short-term prognosis in APE patients using our hospital pulmonary embolism (PE) database (384 patients consecutively collected). Logistic regression analysis and nomograms were applied to construct the predictive model, and validation was assessed. A total of 340 APE patients were included, with a 30-day all-cause mortality rate of 8.5%. The incidence of hypoalbuminemia was 15.9%. The odds ratio (OR) for short-term mortality in patients with high ALB was 0.89 (0.886, 95% CI: 0.812-0.967). Additionally, we created a nomogram for individualized mortality risk prediction. Receiver operating characteristic (ROC) curve analysis showed that the diagnostic area under the curve (AUC) of ALB was 0.758 (95% CI 0.683-0.833), and the best cut-off value was 33.85 g/L. Optimal simplified Pulmonary Embolism Severity Index (sPESI) (ALB combined sPESI) AUC was 0.835 (95% CI 0.775-0.896). Baseline hypoalbuminemia may be an independent prognostic indicator of short-term mortality in patients with APE.
摘要：
血清白蛋白（ALB）与急性肺栓塞（APE）患者短期预后的关系尚不清楚。我们使用我院肺栓塞（PE）数据库（连续收集384例患者）调查了ALB对APE患者短期预后的预测价值。采用Logistic回归分析和列线图构建预测模型，并对验证进行了评估。共纳入340例APE患者，30天全因死亡率为8.5%。低蛋白血症的发生率为15.9%。高ALB患者短期死亡率的比值比(OR)为0.89(0.886,95%CI:0.812-0.967)。此外,我们创建了个体化死亡率风险预测的列线图.受试者工作特征（ROC）曲线分析显示，ALB的诊断曲线下面积（AUC）为0.758（95％CI0.683-0.833），最佳截断值为33.85g/L最佳简化肺栓塞严重程度指数（sPESI）（ALB联合sPESI）AUC为0.835（95％CI0.775-0.896）。基线低白蛋白血症可能是APE患者短期死亡率的独立预后指标。
