PDF(Pubmed)
Abstract：
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging males, affecting 50% of men over 50 and up to 80% of men over 80 years old. Its negative impact on health-related quality of life implores further investigation into its risk factors and strategies for effective management. Although the exact molecular mechanisms underlying pathophysiological onset of BPH are poorly defined, the current hypothesized contributors to BPH and lower urinary tract symptoms (LUTS) include aging, inflammation, metabolic syndrome, and hormonal changes. These processes are indirectly influenced by circadian rhythm disruption. In this article, we review the recent evidence on the potential association of light changes/circadian rhythm disruption and the onset of BPH and impact on treatment.
METHODS: A narrative literature review was conducted using PubMed and Google Scholar to identify supporting evidence. The articles referenced ranged from 1975 to 2023.
RESULTS: A clear relationship between BPH/LUTS and circadian rhythm disruption is yet to be established. However, common mediators influence both diseases, including proinflammatory states, metabolic syndrome, and hormonal regulation that can be asserted to circadian disruption. Some studies have identified a possible relationship between general LUTS and sleep disturbance, but little research has been done on the medical management of these diseases and how circadian rhythm disruption further affects treatment outcomes.
CONCLUSIONS: There is evidence to implicate a relationship between BPH/LUTS and circadian rhythm disruptions. However, there is scarce literature on potential specific link in medical management of the disease and treatment outcomes with circadian rhythm disruption. Further study is warranted to provide BPH patients with insights into circadian rhythm directed appropriate interventions.
METHODS: A narrative literature review was conducted using PubMed and Google Scholar to identify supporting evidence. The articles referenced ranged from 1975 to 2023.
RESULTS: A clear relationship between BPH/LUTS and circadian rhythm disruption is yet to be established. However, common mediators influence both diseases, including proinflammatory states, metabolic syndrome, and hormonal regulation that can be asserted to circadian disruption. Some studies have identified a possible relationship between general LUTS and sleep disturbance, but little research has been done on the medical management of these diseases and how circadian rhythm disruption further affects treatment outcomes.
CONCLUSIONS: There is evidence to implicate a relationship between BPH/LUTS and circadian rhythm disruptions. However, there is scarce literature on potential specific link in medical management of the disease and treatment outcomes with circadian rhythm disruption. Further study is warranted to provide BPH patients with insights into circadian rhythm directed appropriate interventions.
摘要：
背景：良性前列腺增生（BPH）是老年男性最常见的泌尿系疾病，影响50％的50岁以上的男性和80％的80岁以上的男性。它对健康相关生活质量的负面影响需要进一步调查其危险因素和有效管理策略。尽管BPH病理生理发病的确切分子机制尚不明确，目前的假设因素BPH和下尿路症状（LUTS）包括衰老，炎症,代谢综合征,和荷尔蒙的变化。这些过程受到昼夜节律中断的间接影响。在这篇文章中,我们回顾了光变化/昼夜节律紊乱与BPH发病之间潜在关联以及对治疗影响的最新证据.
方法：使用PubMed和GoogleScholar进行了叙述性文献综述，以确定支持证据。引用的文章范围从1975年到2023年。
结果：BPH/LUTS与昼夜节律紊乱之间的明确关系尚未确定。然而,常见的介质影响这两种疾病，包括促炎状态,代谢综合征,和可以断言昼夜节律中断的荷尔蒙调节。一些研究已经确定了一般LUTS和睡眠障碍之间的可能关系，但是关于这些疾病的医疗管理以及昼夜节律中断如何进一步影响治疗结果的研究很少。
结论：有证据表明BPH/LUTS与昼夜节律紊乱之间存在关系。然而,关于疾病的医疗管理和治疗结果与昼夜节律中断的潜在特定联系的文献很少.有必要进行进一步的研究，以提供BPH患者对昼夜节律指导的适当干预措施的见解。
方法：使用PubMed和GoogleScholar进行了叙述性文献综述，以确定支持证据。引用的文章范围从1975年到2023年。
结果：BPH/LUTS与昼夜节律紊乱之间的明确关系尚未确定。然而,常见的介质影响这两种疾病，包括促炎状态,代谢综合征,和可以断言昼夜节律中断的荷尔蒙调节。一些研究已经确定了一般LUTS和睡眠障碍之间的可能关系，但是关于这些疾病的医疗管理以及昼夜节律中断如何进一步影响治疗结果的研究很少。
结论：有证据表明BPH/LUTS与昼夜节律紊乱之间存在关系。然而,关于疾病的医疗管理和治疗结果与昼夜节律中断的潜在特定联系的文献很少.有必要进行进一步的研究，以提供BPH患者对昼夜节律指导的适当干预措施的见解。
