PDF(Pubmed)
Abstract：
Acne vulgaris is one of the most prevalent skin conditions, affecting almost all teenagers worldwide. Multiple factors, including the excessive production of sebum, dysbiosis of the skin microbiome, disruption of keratinization within hair follicles, and local inflammation, are believed to trigger or aggravate acne. Immune activity plays a crucial role in the pathogenesis of acne. Recent research has improved our understanding of the immunostimulatory functions of microorganisms, lipid mediators, and neuropeptides. Additionally, significant advances have been made in elucidating the intricate mechanisms through which cutaneous innate and adaptive immune cells perceive and transmit stimulatory signals and initiate immune responses. However, our understanding of precise temporal and spatial patterns of immune activity throughout various stages of acne development remains limited. This review provides a comprehensive overview of the current knowledge concerning the immune processes involved in the initiation and progression of acne. Furthermore, we highlight the significance of detailed spatiotemporal analyses, including analyses of temporal dynamics of immune cell populations as well as single-cell and spatial RNA sequencing, for the development of targeted therapeutic and prevention strategies.
摘要：
寻常痤疮是最常见的皮肤病之一,影响全世界几乎所有的青少年。多重因素,包括过度生产皮脂，皮肤微生物群的生态失调，毛囊内角质化的破坏，和局部炎症,被认为会引发或加重痤疮。免疫活性在痤疮的发病机制中起着至关重要的作用。最近的研究提高了我们对微生物免疫刺激功能的理解，脂质介质，和神经肽。此外,在阐明皮肤先天和适应性免疫细胞感知和传递刺激信号并启动免疫反应的复杂机制方面取得了重大进展。然而,我们对痤疮发展各个阶段的免疫活动的精确时间和空间模式的理解仍然有限。这篇综述全面概述了当前有关痤疮发生和进展中涉及的免疫过程的知识。此外，我们强调了详细的时空分析的重要性，包括免疫细胞群的时间动力学分析以及单细胞和空间RNA测序，制定有针对性的治疗和预防策略。
