PDF(Pubmed)
Abstract：
Extracellular vesicles (EVs) are membrane-bound particles released by all cells under physiological and pathological conditions. EVs constitute a potential tool to unravel cell-specific pathophysiological mechanisms at the root of disease states and retain the potential to act as biomarkers for cardiac diseases. By being able to carry bioactive cargo (such as proteins and miRNAs), EVs harness great potential as accessible \"liquid biopsies\", given their ability to reflect the state of their cell of origin. Cardiomyopathies encompass a variety of myocardial disorders associated with mechanical, functional and/or electric dysfunction. These diseases exhibit different phenotypes, including inappropriate ventricular hypertrophy, dilatation, scarring, fibro-fatty replacement, dysfunction, and may stem from multiple aetiologies, most often genetic. Thus, the aims of this narrative review are to summarize the current knowledge on EVs and cardiomyopathies (e.g., hypertrophic, dilated and arrhythmogenic), to elucidate the potential role of EVs in the paracrine cell-to-cell communication among cardiac tissue compartments, in aiding the diagnosis of the diverse subtypes of cardiomyopathies in a minimally invasive manner, and finally to address whether certain molecular and phenotypical characteristics of EVs may correlate with cardiomyopathy disease phenotype and severity.
摘要：
细胞外囊泡(EV)是所有细胞在生理和病理条件下释放的膜结合颗粒。EV构成了一种潜在的工具，可以在疾病状态的根源上揭示细胞特异性病理生理机制，并保留作为心脏病生物标志物的潜力。通过能够携带生物活性货物（如蛋白质和miRNA），电动汽车利用巨大的潜力作为“液体活检”，鉴于它们能够反映其起源细胞的状态。心肌病包括各种与机械性，功能和/或电功能障碍。这些疾病表现出不同的表型，包括不适当的心室肥大,扩张,疤痕,纤维脂肪替代，功能障碍,可能源于多种病因，最常见的是遗传。因此，这篇叙述性综述的目的是总结当前关于电动汽车和心肌病的知识(例如，肥大,扩张和致心律失常)，阐明电动汽车在心脏组织区室旁分泌细胞间通讯中的潜在作用，以微创方式帮助诊断不同亚型的心肌病，最后探讨电动汽车的某些分子和表型特征是否与心肌病疾病表型和严重程度相关。
