PDF(Pubmed)
Abstract：
Premature ovarian insufficiency (POI) is a condition in which the quantity of follicles and the quality of oocytes gradually decrease. This results in an estrogen secretion disorder and abnormal follicle development, which can lead to related diseases, early onset of menopause, sexual dysfunction, and an increased risk of cardiovascular issues, osteoporosis, and depression, among others. This disease significantly impacts the physical and mental health and overall quality of life of affected women. Factors such as genetic abnormalities, oophorectomy, radiotherapy for malignancy, idiopathic conditions, and an unhealthy lifestyle, including smoking, can accelerate the depletion of the follicular pool and the onset of menopause. Extensive research has been conducted on the detrimental effects of tobacco smoke on the ovaries. This article aims to review the advancements in understanding the impact of tobacco smoke on POI, both in vivo and in vitro. Furthermore, we explore the potential adverse effects of common toxicants found in tobacco smoke, such as polycyclic aromatic hydrocarbons (PAHs), heavy metals like cadmium, alkaloids like nicotine and its major metabolite cotinine, benzo[a]pyrene, and aromatic amines. In addition to discussing the toxicants, this article also reviews the complications associated with POI and the current state of research and application of treatment methods. These findings will contribute to the development of more precise treatments for POI, offering theoretical support for enhancing the long-term quality of life for women affected by this condition.
摘要：
过早卵巢功能不全（POI）是卵泡数量和卵母细胞质量逐渐降低的一种状况。这导致雌激素分泌紊乱和卵泡发育异常，这可能导致相关疾病，更年期的早期发作，性功能障碍,心血管疾病的风险增加，骨质疏松,和抑郁症,在其他人中。这种疾病严重影响受影响妇女的身心健康和整体生活质量。遗传异常等因素，卵巢切除术,恶性肿瘤的放射治疗，特发性条件，和不健康的生活方式，包括吸烟,可以加速卵泡池的消耗和更年期的开始。已经对烟草烟雾对卵巢的有害影响进行了广泛的研究。本文旨在回顾烟草烟雾对POI影响的研究进展，体内和体外。此外，我们探讨了烟草烟雾中常见毒物的潜在不利影响，如多环芳烃(PAHs)，像镉这样的重金属，生物碱，如尼古丁及其主要代谢产物可替宁，苯并[a]芘,和芳香胺。除了讨论有毒物质，本文还对POI相关并发症及治疗方法的研究和应用现状进行了综述。这些发现将有助于开发更精确的POI治疗方法，为提高受此影响的妇女的长期生活质量提供理论支持。
