PDF(Pubmed)
Abstract：
BACKGROUND: Talaromyces marneffei is endemic to eastern India, Southeast Asia, and Guangdong and Guangxi provinces in China. It is common in immunocompromised individuals, especially in HIV-infected patients.
METHODS: A 66-year-old male who had a history of hypertension and resided in Shandong Province (Northern China) was admitted for recurrent fever for one month. The patient had recurrent fever, multiple lymphadenopathies, hepatosplenomegaly, a back rash, and a progressive decrease in white blood cells and platelets. Talaromyces marneffei was isolated from peripheral blood and bone marrow after admission, and suspected fungal cells were found via lymph node pathology. The patient\'s infection secondary to haemophagocytic syndrome continued to worsen despite antifungal, anti-inflammatory, and symptomatic treatment, leading to death due to multiple-organ failure.
CONCLUSIONS: Although rare, infection due to Talaromyces marneffei in HIV-negative patients has been increasing in recent years, and we should be vigilant about \"new\" infections in nonendemic areas.
METHODS: A 66-year-old male who had a history of hypertension and resided in Shandong Province (Northern China) was admitted for recurrent fever for one month. The patient had recurrent fever, multiple lymphadenopathies, hepatosplenomegaly, a back rash, and a progressive decrease in white blood cells and platelets. Talaromyces marneffei was isolated from peripheral blood and bone marrow after admission, and suspected fungal cells were found via lymph node pathology. The patient\'s infection secondary to haemophagocytic syndrome continued to worsen despite antifungal, anti-inflammatory, and symptomatic treatment, leading to death due to multiple-organ failure.
CONCLUSIONS: Although rare, infection due to Talaromyces marneffei in HIV-negative patients has been increasing in recent years, and we should be vigilant about \"new\" infections in nonendemic areas.
摘要：
背景：马尔尼菲塔拉多菌是印度东部特有的，东南亚,以及中国的广东和广西。在免疫受损的个体中很常见，尤其是HIV感染者。
方法：一名66岁男性，有高血压病史，居住在山东省（中国北方），因反复发烧一个月而入院。病人反复发烧,多发性淋巴结病，肝脾肿大,背部皮疹,白细胞和血小板逐渐减少.入院后从外周血和骨髓中分离出马尔尼菲塔拉酵母，通过淋巴结病理发现可疑真菌细胞。患者继发于噬血细胞综合征的感染继续恶化，尽管有抗真菌药，抗炎,和对症治疗，导致多器官衰竭死亡.
结论：虽然罕见，近年来，在HIV阴性患者中，由于马尔尼菲塔拉菌引起的感染一直在增加，我们应该警惕非流行地区的“新”感染。
方法：一名66岁男性，有高血压病史，居住在山东省（中国北方），因反复发烧一个月而入院。病人反复发烧,多发性淋巴结病，肝脾肿大,背部皮疹,白细胞和血小板逐渐减少.入院后从外周血和骨髓中分离出马尔尼菲塔拉酵母，通过淋巴结病理发现可疑真菌细胞。患者继发于噬血细胞综合征的感染继续恶化，尽管有抗真菌药，抗炎,和对症治疗，导致多器官衰竭死亡.
结论：虽然罕见，近年来，在HIV阴性患者中，由于马尔尼菲塔拉菌引起的感染一直在增加，我们应该警惕非流行地区的“新”感染。
