PDF(Pubmed)
Abstract：
We report on two children who had presented in a poor clinical state after an initial bout of cough, sore throat and fever for a few days. Both of them had multisystemic involvement with fluid-refractory septic shock requiring ionotropic support, intubation and care in the paediatric intensive care unit. Recent significant rise in scarlet fever has led to a significant increase in the number of invasive group A streptococcal infections with increased mortality in paediatric patients. Both of them had co-infection with influenza, which could have led to an increased risk of invasive group A streptococcal (iGAS) infection. After prompt treatment, including early initiation of antibiotics, they both recovered well. To our knowledge, there are no reported cases of iGAS infection from the UK in any medical journal though the fatal cases have been reported to the health statistics department by various National Health Service trusts individually.
摘要：
我们报告了两名儿童，他们在最初的咳嗽发作后表现出不良的临床状态，喉咙痛和发烧几天。他们都有多系统参与流体难治性脓毒性休克需要离子支持，儿科重症监护病房的插管和护理。最近猩红热的显着上升导致侵袭性A组链球菌感染的数量显着增加，儿科患者的死亡率增加。他们两人都同时感染了流感，这可能导致侵袭性A组链球菌（iGAS）感染的风险增加。及时治疗后,包括早期开始使用抗生素，他们都恢复得很好。据我们所知,在任何医学杂志上都没有报告来自英国的iGAS感染病例，尽管致命病例已由各个国家卫生服务信托机构分别报告给卫生统计部门。
