METHODS: Clinical data were obtained from 101, 56, and 116 patients with SNIP, sinonasal squamous cell carcinoma (SNSCC), and unilateral chronic rhinosinusitis (CRS), respectively. Preoperative serum SCCA and CYFRA 21-1 levels were compared, and logistic regression analyses were performed to screen serum tumor markers, which may be used to diagnose SNIP. Diagnostic cut-off values were determined using receiver operating characteristic (ROC) curves, and their diagnostic power was verified.
RESULTS: Serum SCCA and CYFRA 21-1 differentiated SNIP from CRS with the cut-off values of 1.97 ng/mL and 2.64 ng/mL and the areas under the ROC curves (AUC) of 0.895 and 0.766, respectively, and the AUC of the combination of the two markers was 0.909. CYFRA 21-1 differentiated SNIP with malignant transformation from that without malignant transformation with a cut-off value of 3.51 ng/mL and an AUC of 0.938. CYFRA 21-1 distinguished SNIP with malignant transformation from SNSCC with a cut-off value of 3.55 ng/mL and an AUC of 0.767.
CONCLUSIONS: This study provides novel potential diagnostic tools for SNIP by demonstrating the use of serum SCCA and CYFRA 21-1 in the diagnosis of SNIP.
方法:获得了101、56和116例SNIP患者的临床数据,鼻窦鳞状细胞癌(SNSCC),和单侧慢性鼻-鼻窦炎(CRS),分别。术前血清SCCA和CYFRA21-1水平比较,和logistic回归分析用于筛选血清肿瘤标志物,可用于诊断SNIP。使用受试者工作特征(ROC)曲线确定诊断临界值,他们的诊断能力得到了验证。
结果:血清SCCA和CYFRA21-1区分SNIP和CRS的临界值分别为1.97ng/mL和2.64ng/mL,ROC曲线下面积(AUC)分别为0.895和0.766,两种标志物组合的AUC为0.909。CYFRA21-1从没有恶性转化的SNIP中分化出具有恶性转化的SNIP,其临界值为3.51ng/mL,AUC为0.938。CYFRA21-1将具有恶性转化的SNIP与SNSCC区分开,其临界值为3.55ng/mL,AUC为0.767。
结论:本研究通过证明血清SCCA和CYFRA21-1在SNIP诊断中的应用,为SNIP提供了新的潜在诊断工具。