PDF(Pubmed)
Abstract：
In 2019, we conducted a cross-sectional study for polio virus seroprevalence in Guangdong province, China. We assessed the positivity rates of poliomyelitis NA and GMT in serum across various demographic groups, and the current findings were compared with pre-switch data from 2014. Using multistage random sampling method, four counties/districts were randomly selected per city, and within each, one general hospital and two township hospitals were chosen. Healthy individuals coming for medical checkups or vaccination were invited. A total of 1318 individual samples were collected and tested. In non-newborn population, age-dependent positivity rates ranged from 77.8% to 100% for PV1 NA and 70.3% to 98.9% for PV3 NA (p < .01). The lowest GMT values for both types (17.03 and 8.46) occurred in the 20 to <30 years age group, while peak GMTs for PV1 and PV3 were observed in 1 to <2 (340.14) and 0 to <1-year (168.90) age groups, respectively. GMTs for PV1 (P = .002) and PV3 (P = .007) in Eastern Guangdong were lower than those in the other three regions. Male participants showed higher GMTs than females (P = .016 and .033, respectively). In newborn population, both males and females showed higher PV1 NA positivity rates and GMTs compared to PV3 (p < .05). Post-switch PV3 NA positivity rates were higher than pre-switch rates (p = .016). GMTs of both PV1 and PV3 were significantly higher post-switch (p < .001). The positivity rates of NAs and GMTs remain high level, which play an important role in resisting poliomyelitis infection. Effect of the converted immunization program was more pronounced than that before.
摘要：
2019年，我们对广东省脊髓灰质炎病毒血清阳性率进行了横断面研究，中国。我们评估了不同人口群体血清中脊髓灰质炎NA和GMT的阳性率，并将当前发现与2014年的切换前数据进行了比较.采用多级随机抽样方法,每个城市随机选择四个县/区，在每一个之内,选择了一家综合医院和两家乡镇医院。邀请了健康的人来进行体检或接种疫苗。收集并测试了总共1318个个体样品。在非新生儿中，年龄依赖性阳性率PV1NA为77.8%~100%,PV3NA为70.3%~98.9%(p<.01).两种类型的最低GMT值（17.03和8.46）发生在20至<30岁年龄组，而PV1和PV3的峰值GMT在1至<2（340.14）和0至<1岁（168.90）年龄组中观察到，分别。粤东地区PV1（P=.002）和PV3（P=.007）的GMT低于其他三个地区。男性参与者的GMT高于女性（分别为P=.016和.033）。在新生人口中，与PV3相比，男性和女性均显示出更高的PV1NA阳性率和GMT（p<0.05）。切换后的PV3NA阳性率高于切换前的阳性率（p=0.016）。PV1和PV3的GMT在转换后显著较高(p<.001)。NAs和GMT的阳性率保持较高水平，在抵抗脊髓灰质炎感染中起着重要作用。转换后的免疫程序的效果比以前更明显。
