PDF(Pubmed)
Abstract：
The non-ketotic hyperglycemic chorea (NKHC) was a rare complication for patients with diabetes mellitus, but not been well studied. In the present research, we aimed to investigate the clinical and imaging characteristics of NKHC and explore the potential association.
We performed a case-control study with patients diagnosed as NKHC. The patients with group of NKHC were retrospectively recruited, while the matched group were set to screened patients with diabetes mellitus but no NKHC at a 1:3 ratio. The clinical and imaging data were collected for all the participants of the two groups. Firstly, Correlation analysis was conducted to test the difference of all the variables between the NKHC group and matched group. Then, the putative associated factors for NKHC were further identified.
Eleven men and 9 women with NKHC and 60 matched participants were analyzed. The mean age of the NKHC group was 68.5 ± 14.9 years. Participants with NKHC were more likely to have a higher glycosylated hemoglobin (HbA1c) level (13 ± 2.82 vs. 10.57 ± 2.71, P<0.001), and a higher frequency of renal dysfunction (estimated glomerular filtration rates <60 ml/min/1.73m2) (55% vs. 20%, P=0.005). Logistic regression analyses showed that both higher HbA1c and renal dysfunction were significantly correlated with NKHC.
A higher value of HbA1c and renal dysfunction may be associated with the occurrence of NKHC.
We performed a case-control study with patients diagnosed as NKHC. The patients with group of NKHC were retrospectively recruited, while the matched group were set to screened patients with diabetes mellitus but no NKHC at a 1:3 ratio. The clinical and imaging data were collected for all the participants of the two groups. Firstly, Correlation analysis was conducted to test the difference of all the variables between the NKHC group and matched group. Then, the putative associated factors for NKHC were further identified.
Eleven men and 9 women with NKHC and 60 matched participants were analyzed. The mean age of the NKHC group was 68.5 ± 14.9 years. Participants with NKHC were more likely to have a higher glycosylated hemoglobin (HbA1c) level (13 ± 2.82 vs. 10.57 ± 2.71, P<0.001), and a higher frequency of renal dysfunction (estimated glomerular filtration rates <60 ml/min/1.73m2) (55% vs. 20%, P=0.005). Logistic regression analyses showed that both higher HbA1c and renal dysfunction were significantly correlated with NKHC.
A higher value of HbA1c and renal dysfunction may be associated with the occurrence of NKHC.
摘要：
■非酮症高血糖舞蹈症（NKHC）是糖尿病患者的罕见并发症，但没有得到很好的研究。在目前的研究中,我们旨在探讨NKHC的临床和影像学特征,并探讨其潜在的相关性.
■我们对诊断为NKHC的患者进行了病例对照研究。回顾性招募NKHC组患者，而匹配组则以1:3的比例筛选糖尿病但无NKHC的患者。收集两组患者的临床和影像学资料。首先,进行相关分析以检验NKHC组与匹配组之间所有变量的差异。然后，进一步确定了NKHC的推定相关因素.
■分析了11名男性和9名女性NKHC患者以及60名匹配参与者。NKHC组的平均年龄为68.5±14.9岁。患有NKHC的参与者更有可能具有较高的糖基化血红蛋白（HbA1c）水平（13±2.82vs.10.57±2.71，P<0.001），肾功能不全的频率较高（估计肾小球滤过率<60ml/min/1.73m2）（55％vs.20%,P=0.005)。Logistic回归分析显示，高HbA1c和肾功能损害与NKHC显著相关。
■较高的HbA1c值和肾功能障碍可能与NKHC的发生有关。
■我们对诊断为NKHC的患者进行了病例对照研究。回顾性招募NKHC组患者，而匹配组则以1:3的比例筛选糖尿病但无NKHC的患者。收集两组患者的临床和影像学资料。首先,进行相关分析以检验NKHC组与匹配组之间所有变量的差异。然后，进一步确定了NKHC的推定相关因素.
■分析了11名男性和9名女性NKHC患者以及60名匹配参与者。NKHC组的平均年龄为68.5±14.9岁。患有NKHC的参与者更有可能具有较高的糖基化血红蛋白（HbA1c）水平（13±2.82vs.10.57±2.71，P<0.001），肾功能不全的频率较高（估计肾小球滤过率<60ml/min/1.73m2）（55％vs.20%,P=0.005)。Logistic回归分析显示，高HbA1c和肾功能损害与NKHC显著相关。
■较高的HbA1c值和肾功能障碍可能与NKHC的发生有关。
