PDF(Pubmed)
Abstract：
A 27-year-old Japanese woman with a history of depression and an eating disorder presented to our emergency department with a chief complaint of generalized weakness. Electrocardiography showed prominent QT prolongation with multiple ventricular contractions. Chest X-ray plain computed tomography revealed pulmonary edema. Echocardiography showed decreased left ventricular systolic function. Suspecting acute myocarditis, we performed a myocardial biopsy from the right ventricular septum. The biopsy histology revealed extensive myocardial fibrosis and a very mild inflammatory cell infiltrate. In an additional detailed medical interview, the patient admitted that she had consumed three bottles of a first-aid liquid containing naphazoline approximately ~12 h before her presentation, in a suicide attempt. Her QTc and left ventricular ejection fraction improved during hospitalization.
UNASSIGNED: Acute drug intoxication can cause QT prolongation and ventricular arrhythmias, cardiomyopathy, and pulmonary edema. When acute QT prolongation, myocardial damage, and pulmonary edema are seen (suggesting acute myocarditis), naphazoline intoxication should be investigated in the differential diagnosis.
UNASSIGNED: Acute drug intoxication can cause QT prolongation and ventricular arrhythmias, cardiomyopathy, and pulmonary edema. When acute QT prolongation, myocardial damage, and pulmonary edema are seen (suggesting acute myocarditis), naphazoline intoxication should be investigated in the differential diagnosis.
摘要：
一名27岁的日本女性，有抑郁症和饮食失调史，向我们的急诊科就诊，主要主诉为全身无力。心电图显示明显的QT延长伴多次心室收缩。胸部X线平片显示肺水肿。超声心动图显示左心室收缩功能下降。怀疑急性心肌炎,我们从右室间隔进行了心肌活检.活检组织学显示广泛的心肌纤维化和非常轻度的炎症细胞浸润。在额外的详细医疗采访中，患者承认，她在就诊前约12小时服用了三瓶含有萘甲唑啉的急救液，企图自杀.住院期间QTc和左心室射血分数有所改善。
■急性药物中毒可引起QT延长和室性心律失常，心肌病,和肺水肿。当急性QT延长时，心肌损伤,可见肺水肿（提示急性心肌炎），在鉴别诊断中应研究萘甲唑啉中毒。
■急性药物中毒可引起QT延长和室性心律失常，心肌病,和肺水肿。当急性QT延长时，心肌损伤,可见肺水肿（提示急性心肌炎），在鉴别诊断中应研究萘甲唑啉中毒。
