PDF(Pubmed)
Abstract：
UNASSIGNED: Because size-based imaging criteria poorly capture biologic response in desmoid-type fibromatosis (DF), changes in MRI T2 signal intensity are frequently used as a response surrogate, but remain qualitative. We hypothesized that absolute quantification of DF T2 relaxation time derived from parametric T2 maps would be a feasible and effective imaging biomarker of disease activity.
UNASSIGNED: This IRB-approved retrospective study included 11 patients with DF, managed by observation or systemic therapy, assessed by 3T MRI. Tumor maximum diameter, volume, and T2-weighted signal intensity were derived from manual tumor segmentations. Tumor:muscle T2 signal ratios were recorded. Two readers measured tumor T2 relaxation times using a commercial T2 scanning sequence, manual ROI delineation and commercial calculation software enabling estimation of reader reliability. Objective response rates based on RECIST1.1 and best responses were compared between size-based and signal-based parameters.
UNASSIGNED: Median patient age was 52.6 years; 8 subjects were female (73%). Nine patients with longitudinal assessments were followed for an average of 314 days. Median baseline tumor diameter was 7.2 cm (range 4.4 - 18.2 cm). Median baseline T2 was 65.1 ms (range 40.4 - 94.8 ms, n=11); median at last follow-up was 44.3 ms (-32% from baseline; range 29.3 - 94.7 ms, n=9). T2 relaxation times correlated with tumor:muscle T2 signal ratios, Spearman p=0.78 (p<0.001). T2 mapping showed high inter-reader reliability, ICC=0.84. The best response as a percentage change in T2 values was statistically significant (mean -17.9%, p=0.05, paired t-test) while change in diameter was not (mean -8.9%, p=0.12).
UNASSIGNED: Analysis of T2 relaxation time maps of DF may offer a feasible quantitative biomarker for assessing the extent of response to treatment. This approach may have high inter-reader reliability.
UNASSIGNED: This IRB-approved retrospective study included 11 patients with DF, managed by observation or systemic therapy, assessed by 3T MRI. Tumor maximum diameter, volume, and T2-weighted signal intensity were derived from manual tumor segmentations. Tumor:muscle T2 signal ratios were recorded. Two readers measured tumor T2 relaxation times using a commercial T2 scanning sequence, manual ROI delineation and commercial calculation software enabling estimation of reader reliability. Objective response rates based on RECIST1.1 and best responses were compared between size-based and signal-based parameters.
UNASSIGNED: Median patient age was 52.6 years; 8 subjects were female (73%). Nine patients with longitudinal assessments were followed for an average of 314 days. Median baseline tumor diameter was 7.2 cm (range 4.4 - 18.2 cm). Median baseline T2 was 65.1 ms (range 40.4 - 94.8 ms, n=11); median at last follow-up was 44.3 ms (-32% from baseline; range 29.3 - 94.7 ms, n=9). T2 relaxation times correlated with tumor:muscle T2 signal ratios, Spearman p=0.78 (p<0.001). T2 mapping showed high inter-reader reliability, ICC=0.84. The best response as a percentage change in T2 values was statistically significant (mean -17.9%, p=0.05, paired t-test) while change in diameter was not (mean -8.9%, p=0.12).
UNASSIGNED: Analysis of T2 relaxation time maps of DF may offer a feasible quantitative biomarker for assessing the extent of response to treatment. This approach may have high inter-reader reliability.
摘要：
■因为基于尺寸的成像标准很难捕获纤维瘤病（DF）的生物学反应，MRIT2信号强度的变化经常被用作反应替代，但保持定性。我们假设从参数T2图得出的DFT2弛豫时间的绝对定量将是疾病活动的可行和有效的成像生物标志物。
■这项IRB批准的回顾性研究包括11例DF患者，通过观察或全身治疗，通过3TMRI评估。肿瘤最大直径,volume,和T2加权信号强度来自手动肿瘤分割。记录肿瘤:肌肉T2信号比。两个读取器使用商业T2扫描序列测量肿瘤T2弛豫时间，手动ROI描述和商业计算软件，使读者的可靠性估计。在基于大小和基于信号的参数之间比较了基于RECIST1.1的客观反应率和最佳反应。
■患者年龄中位数为52.6岁;8名受试者为女性(73%)。对9名进行纵向评估的患者进行了平均314天的随访。中位基线肿瘤直径为7.2cm(范围4.4-18.2cm)。中位基线T2为65.1ms（范围40.4-94.8ms，n=11）；最后一次随访的中位数为44.3ms（距基线-32％；范围29.3-94.7ms，n=9)。T2弛豫时间与肿瘤相关：肌肉T2信号比，Spearmanp=0.78(p<0.001)。T2映射显示出较高的读取器间可靠性，ICC=0.84。作为T2值变化百分比的最佳响应具有统计学意义（平均值-17.9％，p=0.05，配对t检验），而直径变化不（平均值-8.9%，p=0.12）。
■DF的T2弛豫时间图的分析可以提供用于评估对治疗的反应程度的可行的定量生物标志物。该方法可以具有高的读取器间可靠性。
■这项IRB批准的回顾性研究包括11例DF患者，通过观察或全身治疗，通过3TMRI评估。肿瘤最大直径,volume,和T2加权信号强度来自手动肿瘤分割。记录肿瘤:肌肉T2信号比。两个读取器使用商业T2扫描序列测量肿瘤T2弛豫时间，手动ROI描述和商业计算软件，使读者的可靠性估计。在基于大小和基于信号的参数之间比较了基于RECIST1.1的客观反应率和最佳反应。
■患者年龄中位数为52.6岁;8名受试者为女性(73%)。对9名进行纵向评估的患者进行了平均314天的随访。中位基线肿瘤直径为7.2cm(范围4.4-18.2cm)。中位基线T2为65.1ms（范围40.4-94.8ms，n=11）；最后一次随访的中位数为44.3ms（距基线-32％；范围29.3-94.7ms，n=9)。T2弛豫时间与肿瘤相关：肌肉T2信号比，Spearmanp=0.78(p<0.001)。T2映射显示出较高的读取器间可靠性，ICC=0.84。作为T2值变化百分比的最佳响应具有统计学意义（平均值-17.9％，p=0.05，配对t检验），而直径变化不（平均值-8.9%，p=0.12）。
■DF的T2弛豫时间图的分析可以提供用于评估对治疗的反应程度的可行的定量生物标志物。该方法可以具有高的读取器间可靠性。
