PDF(Pubmed)
Abstract：
Desmoglein-2 (DSG2) is a calcium-binding single pass transmembrane glycoprotein and a member of the large cadherin family. Until recently, DSG2 was thought to only function as a cell adhesion protein embedded within desmosome junctions designed to enable cells to better tolerate mechanical stress. However, additional roles for DSG2 outside of desmosomes are continuing to emerge, particularly in cancer. Herein, we review the current literature on DSG2 in cancer and detail its impact on biological functions such as cell adhesion, proliferation, migration, invasion, intracellular signaling, extracellular vesicle release and vasculogenic mimicry. An increased understanding of the diverse repertoire of the biological functions of DSG2 holds promise to exploit this cell surface protein as a potential prognostic biomarker and/or target for better patient outcomes. This review explores the canonical and non-canonical functions of DSG2, as well as the context-dependent impacts of DSG2 in the realm of cancer.
摘要：
Desmoglein-2（DSG2）是一种钙结合的单次跨膜糖蛋白，是大型钙粘蛋白家族的成员。直到最近,DSG2被认为仅作为嵌入桥粒连接处的细胞粘附蛋白起作用，旨在使细胞更好地耐受机械应力。然而,DSG2在桥粒之外的其他角色正在继续出现，特别是在癌症中。在这里，我们回顾了目前关于DSG2在癌症中的文献，并详细介绍了其对细胞粘附等生物学功能的影响，扩散,迁移,入侵,细胞内信号，细胞外囊泡释放和血管生成拟态。对DSG2生物学功能的多样性的理解增加有望利用该细胞表面蛋白作为潜在的预后生物标志物和/或靶标，以获得更好的患者结果。这篇综述探讨了DSG2的规范和非规范功能，以及DSG2在癌症领域的上下文相关影响。
