A rare case of cerebral phaeohyphomycosis caused by Fonsecaea species in a renal transplant patient.

肾移植患者中由 Fonsecaea 物种引起的罕见脑型真菌病。

• 发表时间: 2024 Mar
• 来源期刊: Med Mycol Case Rep
• DOI: 10.1016/j.mmcr.2023.100621
• PMID: 38187996
• 文章类型: Case Reports
• 作者列表: Qureshi HUH,Absar M,Nasser W,Yacoubi MT

关键词: Brain infection; Cerebral; Cerebral phaeohyphomycosis; Fonsecaea; Neurotropic fungi

Abstract

Cerebral phaeohyphomycosis (CP) is a serious form of phaeohyphomycosis. We report a case of CP caused by Fonsecaea species in a 66-year-old immunocompromised renal transplant recipient female. Craniotomy was performed on an irregularly enhancing right cerebellar hemisphere lesion and abscess and tissue samples collected for microbiological and histological evaluation, showing fungal elements and Fonsecaea species was isolated. Antifungal treatment with voriconazole & liposomal amphotericin B was initiated with a temporary improvement in the patient\'s condition. Deep vein thrombosis jeopardized patient\'s prognosis. Despite aggressive surgical and medical intervention, our patient succumbed to the disease. Historically, CP has been linked with fatality rates as high as 65 %, despite surgical intervention and systemic antifungal medication.

摘要

脑型真菌病（CP）是一种严重的真菌病。我们报告了一名66岁的免疫功能低下的肾移植受者女性中由Fonsecaea物种引起的CP病例。对不规则增强的右小脑半球病变和脓肿进行开颅手术，并收集组织样本进行微生物学和组织学评估。显示真菌元素和Fonsecaea物种被分离。开始使用伏立康唑和脂质体两性霉素B的抗真菌治疗，患者病情暂时改善。深静脉血栓形成危及患者预后。尽管采取了积极的手术和医疗干预措施，我们的病人死于疾病.历史上,CP与高达65%的死亡率有关，尽管进行了手术干预和全身抗真菌药物治疗。