关键词: Cushing's syndrome Endocrine hypertension adrenal disorders monogenic hypertension pheochromocytoma primary aldosteronism (PA)

来  源:   DOI:10.17925/EE.2023.19.2.11   PDF(Pubmed)

Abstract:
Hypertension affects about 1.28 billion adults globally, and significantly increases the risk of chronic morbidity and mortality among sufferers. About 15% of these individuals have secondary hypertension, the majority of whom have dysfunction of one or more endocrine systems as the cause of hypertension. Although adrenal disorders are often identified as the cause of endocrine hypertension, extra-adrenal disease and pituitary disorders also can cause the disease. Timely diagnosis is of paramount importance, because of the potential for a surgical cure or optimal disease control with pharmacotherapy to prevent hypertensive complications. Even with its relatively high prevalence compared with many other chronic illnesses, the diagnosis of endocrine hypertension is often delayed or never made because of poor awareness about the disease among physicians. This review attempts to provide an overview of the disease, with some practical aspects of diagnosis and management of a few of the important disorders causing endocrine hypertension.
摘要:
高血压影响全球约12.8亿成年人,并显著增加患者慢性发病率和死亡率的风险。这些人中约有15%患有继发性高血压,其中大多数患有一个或多个内分泌系统的功能障碍是高血压的原因。虽然肾上腺疾病通常被认为是内分泌高血压的原因,肾上腺外疾病和垂体疾病也可引起这种疾病。及时诊断至关重要,因为有可能通过药物治疗进行手术治愈或最佳的疾病控制,以预防高血压并发症。即使与许多其他慢性疾病相比,其患病率相对较高,内分泌性高血压的诊断往往由于内科医生对该病的认识不足而延迟或从未诊断。这篇综述试图提供该疾病的概述,一些引起内分泌高血压的重要疾病的诊断和管理的一些实际方面。
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