PDF(Pubmed)
Abstract：
UNASSIGNED: Chronic liver disease (CLD) is one of the important causes of morbidity and mortality in our country, and since the damage to the liver is irreversible, we have to look for many severity markers or predictors for the prognosis of the patient. In this study, we have tried to correlate the level of serum uric acid (UA) with the severity of CLD presented as a Child-Pugh score.
UNASSIGNED: A cross-sectional observational study was conducted at Vijayanagar Institute of Medical Science (VIMS), Ballari, Karnataka, from October 2015 to June 2017 in the Department of General Medicine. Fifty patients diagnosed with CLD, aged between 18 and 65 years, of either gender, were enrolled in the study. Serum UA levels were measured, and liver function and coagulation parameters were assessed. A statistical analysis was performed to evaluate the association between serum UA levels, liver function test, and coagulation parameters.
UNASSIGNED: In our study, the mean serum UA level was 6.52 mg/dl and was raised in patients with CLD in correlation to its severity. Alcoholic liver disease (ALD) was the most common etiology for CLD (80%) followed by hepatitis B (Hep B) virus infection (12%) and hepatitis C (Hep C) virus infection (6%). Serum UA levels increased as the Child-Turcotte-Pugh (CTP) score increased. The mean UA level in CTP class C was 8.29 mg/dl. Various parameters such as serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase, total bilirubin, international normalized ratio (INR), calcium, and albumin were significantly associated with serum UA levels in CLD patients.
UNASSIGNED: The correlation between rising blood UA levels and the Child-Pugh score shows that UA estimate may be a valid and affordable indicator for assessing the extent of liver cirrhosis in CLD.
UNASSIGNED: A cross-sectional observational study was conducted at Vijayanagar Institute of Medical Science (VIMS), Ballari, Karnataka, from October 2015 to June 2017 in the Department of General Medicine. Fifty patients diagnosed with CLD, aged between 18 and 65 years, of either gender, were enrolled in the study. Serum UA levels were measured, and liver function and coagulation parameters were assessed. A statistical analysis was performed to evaluate the association between serum UA levels, liver function test, and coagulation parameters.
UNASSIGNED: In our study, the mean serum UA level was 6.52 mg/dl and was raised in patients with CLD in correlation to its severity. Alcoholic liver disease (ALD) was the most common etiology for CLD (80%) followed by hepatitis B (Hep B) virus infection (12%) and hepatitis C (Hep C) virus infection (6%). Serum UA levels increased as the Child-Turcotte-Pugh (CTP) score increased. The mean UA level in CTP class C was 8.29 mg/dl. Various parameters such as serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase, total bilirubin, international normalized ratio (INR), calcium, and albumin were significantly associated with serum UA levels in CLD patients.
UNASSIGNED: The correlation between rising blood UA levels and the Child-Pugh score shows that UA estimate may be a valid and affordable indicator for assessing the extent of liver cirrhosis in CLD.
摘要：
■慢性肝病(CLD)是我国发病和死亡的重要原因之一,由于对肝脏的损害是不可逆转的，我们必须寻找患者预后的许多严重程度标志物或预测因子.在这项研究中,我们尝试将血清尿酸(UA)水平与以Child-Pugh评分表示的CLD严重程度相关联.
■在Vijayanagar医学科学研究所（VIMS）进行了一项横断面观察性研究，巴拉里,卡纳塔克邦,从2015年10月至2017年6月在普通医学系。50名诊断为CLD的患者，年龄在18至65岁之间，无论男女，参加了这项研究。测定血清UA水平,评估肝功能和凝血指标。进行了统计分析以评估血清UA水平之间的关联，肝功能检查,和凝血参数。
■在我们的研究中，CLD患者的平均血清UA水平为6.52mg/dl,与严重程度相关,血清UA水平升高.酒精性肝病（ALD）是CLD的最常见病因（80％），其次是乙型肝炎（HepB）病毒感染（12％）和丙型肝炎（HepC）病毒感染（6％）。血清UA水平随着Child-Turcotte-Pugh（CTP）评分的增加而增加。CTPC类的平均UA水平为8.29mg/dl。各种参数，如血清天冬氨酸氨基转移酶（AST），丙氨酸转氨酶(ALT),碱性磷酸酶,总胆红素,国际标准化比率(INR)，钙，和白蛋白与CLD患者血清UA水平显著相关。
■血液UA水平升高与Child-Pugh评分之间的相关性表明，UA估计值可能是评估CLD肝硬化程度的有效且负担得起的指标。
■在Vijayanagar医学科学研究所（VIMS）进行了一项横断面观察性研究，巴拉里,卡纳塔克邦,从2015年10月至2017年6月在普通医学系。50名诊断为CLD的患者，年龄在18至65岁之间，无论男女，参加了这项研究。测定血清UA水平,评估肝功能和凝血指标。进行了统计分析以评估血清UA水平之间的关联，肝功能检查,和凝血参数。
■在我们的研究中，CLD患者的平均血清UA水平为6.52mg/dl,与严重程度相关,血清UA水平升高.酒精性肝病（ALD）是CLD的最常见病因（80％），其次是乙型肝炎（HepB）病毒感染（12％）和丙型肝炎（HepC）病毒感染（6％）。血清UA水平随着Child-Turcotte-Pugh（CTP）评分的增加而增加。CTPC类的平均UA水平为8.29mg/dl。各种参数，如血清天冬氨酸氨基转移酶（AST），丙氨酸转氨酶(ALT),碱性磷酸酶,总胆红素,国际标准化比率(INR)，钙，和白蛋白与CLD患者血清UA水平显著相关。
■血液UA水平升高与Child-Pugh评分之间的相关性表明，UA估计值可能是评估CLD肝硬化程度的有效且负担得起的指标。
