PDF(Pubmed)
Abstract：
Adamantinoma, constituting a minute fraction of primary bone tumors, poses a diagnostic challenge due to its ambiguous histogenesis. This report outlines a distinctive case involving a 27-year-old female with a history of right tibial adamantinoma, presenting with bilateral pulmonary emboli and metastasis to the ovaries and pelvic lymph nodes. Following en bloc resection five years earlier, the patient underwent debulking surgery with hyperthermic intraperitoneal chemotherapy (HIPIC) and intraoperative radiotherapy (IORT) as a palliative measure. The procedure achieved substantial pelvic tumor reduction, and subsequent follow-ups indicated a favorable postoperative trajectory. This case underscores the rarity of adamantinoma metastasis to the ovaries and pelvis, being the first reported instance, shedding light on the challenges and potential benefits of a multimodal palliative approach. Further research is warranted to refine treatment strategies for metastatic adamantinoma and enhance patient outcomes.
摘要：
Adamantinoma,构成原发性骨肿瘤的一小部分，由于其不明确的组织发生，因此提出了诊断挑战。本报告概述了一个独特的病例，涉及一名27岁的女性，有右胫骨金刚烷胺瘤的病史，表现为双侧肺栓塞并转移至卵巢和盆腔淋巴结。五年前的整块切除术后，作为姑息措施,患者接受了减积手术,包括腹腔热灌注化疗(HIPIC)和术中放疗(IORT).该手术实现了骨盆肿瘤的实质性缩小，随后的随访表明良好的术后轨迹。该病例强调了金刚烷胺瘤罕见地转移到卵巢和骨盆，作为第一个报告的实例，揭示了多模式姑息治疗方法的挑战和潜在好处。需要进一步的研究来完善转移性金刚烷瘤的治疗策略并提高患者的预后。
