Abstract：
It has been reported that toll-like receptors (TLRs) are the main innate immune receptors that recognize gram-positive pathogen-associated molecular patterns (PAMPs). The molecules can induce expression of the innate immune-related molecules that are essential against the bacteria. Streptococcus mutans (S. mutans) is a potential caries-associated pathogen, and innate immunity plays a key role in inhibiting its development and the progression of inflammatory responses. Recently, the roles played by TLRs against S. mutans and the induction of inflammatory responses were evaluated by several investigations. This review article discusses updated information regarding the roles played by TLRs and their potential therapeutic effects against S. mutans.
摘要：
据报道，toll样受体（TLR）是识别革兰氏阳性病原体相关分子模式（PAMP）的主要先天免疫受体。这些分子可以诱导对细菌必需的先天免疫相关分子的表达。变形链球菌(S.mutans）是一种潜在的龋齿相关病原体，和先天免疫在抑制其发展和炎症反应的进展中起关键作用。最近,通过多项研究评估了TLRs在抗变形链球菌和诱导炎症反应方面的作用.这篇综述文章讨论了有关TLRs的作用及其对变形链球菌的潜在治疗作用的最新信息。
