Abstract：
Objective: To understand the changes in pain and its effects in patients with the diagnosis of herpes zoster. Methods: A total of 3 487 patients diagnosed with herpes zoster (HZ) for the first time at the outpatient department of Miyun District Hospital from January 1, 2017, to December 31, 2019, were included in the study. The information of patients was registered and issued with a record card. Patients were required to record the time of pain and rash by themselves. Telephone follow-up was conducted at 21, 90, 180 and 365 days after the onset of rashes, including hospitalization, location of rash and pain, and the time of start and end. The impact of pain on life was evaluated by the Zoster Brief Pain Inventory (ZBPI). Results: The age of 2 999 HZ patients included in the analysis were (53±16) years old, including 1 377 (45.91%) males and 1 903 (63.45%) patients aged 50 years and older. After 21 days of rash, mild, moderate and severe pain accounted for 20.87% (626 cases), 37.98% (1 139 cases) and 33.81% (1 014 cases), respectively. Only 5.07% (152 cases) had no pain or discomfort, and 2.27% (68 cases) had no pain but discomfort. Most of the pain sites were consistent with the rash sites. The chest and back and waist and abdomen were the most common, accounting for 35.58% (1 067 cases) and 29.18% (875 cases), respectively, followed by the limbs and face and neck, accounting for 16.74% (502 cases) and 16.40% (492 cases), respectively. The M (Q1, Q3) of pain days in the HZ patients was 14 (8, 20) days, and the incidence of post-herpetic neuralgia (PHN) was 6.63% (171/2 580) (excluding 419 patients who refused to visit or lost to visit on 90 days after the onset of rash). The pain score of HZ patients within 21 days after the rash was (5.19±2.73) points, and the pain score of PHN patients was (7.61±2.13) points, which was significantly higher than that of non-PHN patients [(5.04±2.69) points] (P<0.001). Daily activities, emotions, walking ability, work, social interaction, sleep and recreation were affected for 21 days after the rash in HZ patients, ranging from 60.79% to 83.83%, with sleep being the most affected (83.83%). The impact scores of pain and life dimensions in PHN patients ranged from 4.59 to 7.61 points on the ZBPI scale, which were higher than those in non-PHN patients (2.49-5.04) (t values ranged from 8.86 to 11.67, all P values <0.001). Conclusion: The proportion of pain in HZ patients after the diagnosis is high, and the pain is more obvious in patients with PHN and HZ patients aged 50 and older, which has a greater impact on their daily lives.
目的： 了解带状疱疹就诊病例疼痛变化情况及其影响。 方法： 将2017年1月1日至2019年12月31日密云区医院门诊首次就诊并被诊断为带状疱疹（HZ）的3 487例病例纳入研究。登记对象资料并发放记录卡，病例自行记录疼痛时间和出疹时间等信息。分别在病例出现皮疹后21、90、180和365 d进行电话随访，内容包括住院情况、出疹与疼痛出现的部位、开始和结束时间，以HZ简易疼痛量表（ZBPI）评价疼痛对生活的影响。 结果： 纳入分析的2 999例HZ病例年龄为（53±16）岁，其中男性1 377例（45.91%），50岁及以上1 903例（63.45%），出疹后21 d轻、中和重度疼痛分别占20.87%（626例）、37.98%（1 139例）和33.81%（1 014例），无痛感和不适感者仅占5.07%（152例），无痛感但有不适感者占2.27%（68例）。疼痛部位多与皮疹部位一致，胸背部和腰腹部多见，分别占35.58%（1 067例）和29.18%（875例），其次为四肢和面颈部，分别占16.74%（502例）和16.40%（492例）。HZ病例疼痛天数的M（Q1，Q3）为14（8，20）d，带状疱疹后神经痛（PHN）发生率为6.63%（171/2 580）（剔除出疹后90 d拒访或失访的419例病例）。HZ病例出疹后21 d内疼痛评分为（5.19±2.73）分，其中PHN病例疼痛评分为（7.61±2.13）分，明显高于非PHN病例［（5.04±2.69）分］（P<0.001）。HZ病例出疹21 d后日常活动、情绪、行走能力、工作、社交、睡眠和娱乐方面受影响比例范围为60.79%~83.83%，以睡眠所受影响较大（83.83%），其中PHN病例在ZBPI量表中疼痛与生活维度的影响评分范围为4.59~7.61分，高于非PHN病例（2.49~5.04）（t值范围为8.86~11.67，均P<0.001）。 结论： 带状疱疹就诊病例出疹后疼痛比例高，PHN和50岁及以上带状疱疹病例疼痛更明显，对生活影响更大。.
目的： 了解带状疱疹就诊病例疼痛变化情况及其影响。 方法： 将2017年1月1日至2019年12月31日密云区医院门诊首次就诊并被诊断为带状疱疹（HZ）的3 487例病例纳入研究。登记对象资料并发放记录卡，病例自行记录疼痛时间和出疹时间等信息。分别在病例出现皮疹后21、90、180和365 d进行电话随访，内容包括住院情况、出疹与疼痛出现的部位、开始和结束时间，以HZ简易疼痛量表（ZBPI）评价疼痛对生活的影响。 结果： 纳入分析的2 999例HZ病例年龄为（53±16）岁，其中男性1 377例（45.91%），50岁及以上1 903例（63.45%），出疹后21 d轻、中和重度疼痛分别占20.87%（626例）、37.98%（1 139例）和33.81%（1 014例），无痛感和不适感者仅占5.07%（152例），无痛感但有不适感者占2.27%（68例）。疼痛部位多与皮疹部位一致，胸背部和腰腹部多见，分别占35.58%（1 067例）和29.18%（875例），其次为四肢和面颈部，分别占16.74%（502例）和16.40%（492例）。HZ病例疼痛天数的M（Q1，Q3）为14（8，20）d，带状疱疹后神经痛（PHN）发生率为6.63%（171/2 580）（剔除出疹后90 d拒访或失访的419例病例）。HZ病例出疹后21 d内疼痛评分为（5.19±2.73）分，其中PHN病例疼痛评分为（7.61±2.13）分，明显高于非PHN病例［（5.04±2.69）分］（P<0.001）。HZ病例出疹21 d后日常活动、情绪、行走能力、工作、社交、睡眠和娱乐方面受影响比例范围为60.79%~83.83%，以睡眠所受影响较大（83.83%），其中PHN病例在ZBPI量表中疼痛与生活维度的影响评分范围为4.59~7.61分，高于非PHN病例（2.49~5.04）（t值范围为8.86~11.67，均P<0.001）。 结论： 带状疱疹就诊病例出疹后疼痛比例高，PHN和50岁及以上带状疱疹病例疼痛更明显，对生活影响更大。.
摘要：
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