Abstract:
Allergen-specific Th2 cells refer to a subset of Th2 cells that undergo substantial expansion following allergen stimulation. They play a crucial role in allergic diseases, and an increasing amount of research has revealed a close relationship between surface molecules on allergen-specific Th2 cells and allergic diseases. In comparison to other CD4+T cells or Th2 cells, allergen-specific Th2 cells exhibit low expression of CD27 but high expression of CD154, CD69, CRTH2, CD161, ST2, hPGDs, CD49d, and COX-2. They can be used for the identification of allergen-specific Th2 cells and serve as potential targets for the prevention and treatment of specific diseases. They hold significant value in preventing the onset and exacerbation of allergic diseases.
过敏原特异性Th2细胞指的是一类受到过敏原刺激后大量扩增的Th2细胞亚群,它在过敏性疾病中发挥重要作用,越来越多的研究发现过敏原特异性Th2细胞的表面分子及其与过敏性疾病之间有密切的关系。相比于其他CD4+T细胞或Th2细胞,过敏原特异性Th2细胞低表达CD27,高表达CD154、CD69、CRTH2、CD161、ST2、hPGDs、CD49d、COX-2,它们可作为过敏原特异性Th2细胞的标志,且可作为预防与治疗特异性疾病的潜在靶点,对预防过敏性疾病发病及加重具有重要的价值。.