PDF(Pubmed)
Abstract：
Neurodegeneration is a complex process involving various inflammatory mediators and cellular responses. Aldose reductase (AR) is a key enzyme in the polyol pathway, which converts glucose to sorbitol. Beyond its metabolic role, AR has also been found to play a significant role in modulating neuroinflammation. This review aims to provide an overview of the current knowledge regarding the involvement of AR inhibition in attenuating neuroinflammation and complications from diabetic neuropathies. Here, we review the literature regarding AR and neuropathy/neurodegeneration. We discuss the mechanisms underlying the influence of AR inhibitors on ocular inflammation, beta-amyloid-induced neurodegeneration, and optic nerve degeneration. Furthermore, potential therapeutic strategies targeting AR in neurodegeneration are explored. The understanding of AR\'s role in neurodegeneration may lead to the development of novel therapeutic interventions for other neuroinflammatory disorders.
摘要：
神经变性是涉及各种炎症介质和细胞反应的复杂过程。醛糖还原酶（AR）是多元醇途径中的关键酶，将葡萄糖转化为山梨糖醇。除了它的新陈代谢作用，还发现AR在调节神经炎症中起重要作用。这篇综述旨在概述有关AR抑制参与减轻糖尿病神经病变的神经炎症和并发症的当前知识。这里,我们回顾了有关AR和神经病变/神经变性的文献。我们讨论了AR抑制剂对眼部炎症影响的潜在机制，β-淀粉样蛋白诱导的神经变性，和视神经退化。此外，探索了针对神经变性AR的潜在治疗策略。对AR在神经变性中的作用的理解可能导致对其他神经炎性疾病的新型治疗干预措施的发展。
