PDF(Pubmed)
Abstract：
BACKGROUND: The effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain relatively unknown.
OBJECTIVE: We present this original paper where we analyzed 60 parturients, at term, 30 without associated infection (C-) and 30 with associated infection (C+), present at birth.
METHODS: We analyzed the blood count and placental microscopic structure through classical and immunohistochemical staining and observed the placental areas affected by the presence of SARS-CoV-2.
RESULTS: SARS-CoV-2 infection was accompanied by a decrease in the number of lymphocytes, the number of platelets and the presence of placental structural changes, identifying extensive areas of amyloid deposits, placental infarcts, vascular thrombosis, syncytial knots, with a decrease in placental vascular density and the presence of infection in the cells located at decidual level, at syncytiotrophoblast level and at the level of the cells of the chorionic plate, still without overcoming this barrier and without causing any fetal infection in the analyzed cases.
CONCLUSIONS: This study shows that the invasion of SARS-CoV-2 in the placenta can produce significant structural changes, with a decrease in placental vascular density that can have significant implications on proper fetal perfusion. Also, the presence of immunoreactivity at the level of decidua, the placental villi, as well as the chorionic plate proves that the virus can overcome the maternal-fetal barrier. However, in the analyzed cases there were no fetal infections at birth, which may show that local placental factors can be a protective filter for the fetus.
OBJECTIVE: We present this original paper where we analyzed 60 parturients, at term, 30 without associated infection (C-) and 30 with associated infection (C+), present at birth.
METHODS: We analyzed the blood count and placental microscopic structure through classical and immunohistochemical staining and observed the placental areas affected by the presence of SARS-CoV-2.
RESULTS: SARS-CoV-2 infection was accompanied by a decrease in the number of lymphocytes, the number of platelets and the presence of placental structural changes, identifying extensive areas of amyloid deposits, placental infarcts, vascular thrombosis, syncytial knots, with a decrease in placental vascular density and the presence of infection in the cells located at decidual level, at syncytiotrophoblast level and at the level of the cells of the chorionic plate, still without overcoming this barrier and without causing any fetal infection in the analyzed cases.
CONCLUSIONS: This study shows that the invasion of SARS-CoV-2 in the placenta can produce significant structural changes, with a decrease in placental vascular density that can have significant implications on proper fetal perfusion. Also, the presence of immunoreactivity at the level of decidua, the placental villi, as well as the chorionic plate proves that the virus can overcome the maternal-fetal barrier. However, in the analyzed cases there were no fetal infections at birth, which may show that local placental factors can be a protective filter for the fetus.
摘要：
背景：怀孕期间严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染的影响仍然相对未知。
目的：我们提出了这篇原始论文，其中我们分析了60例产妇，在学期,30例无相关感染（C-）和30例相关感染（C+），出生时的礼物。
方法：我们通过经典和免疫组织化学染色分析了血细胞计数和胎盘微观结构，并观察了受SARS-CoV-2存在影响的胎盘区域。
结果:SARS-CoV-2感染伴随着淋巴细胞数量的减少,血小板的数量和胎盘结构变化的存在，确定淀粉样蛋白沉积物的广泛区域，胎盘梗塞,血管血栓形成,合胞体结,随着胎盘血管密度的降低和位于蜕膜水平的细胞中感染的存在，在合胞体滋养层细胞水平和绒毛膜板细胞水平，在分析的病例中，仍然没有克服这一障碍，也没有引起任何胎儿感染。
结论：这项研究表明，SARS-CoV-2在胎盘中的入侵可以产生明显的结构变化，胎盘血管密度降低，可能对适当的胎儿灌注产生重大影响。此外，蜕膜水平存在免疫反应性，胎盘绒毛，以及绒毛膜板证明病毒可以克服母胎屏障。然而,在分析的病例中，出生时没有胎儿感染，这可能表明局部胎盘因素可能是胎儿的保护性过滤器。
目的：我们提出了这篇原始论文，其中我们分析了60例产妇，在学期,30例无相关感染（C-）和30例相关感染（C+），出生时的礼物。
方法：我们通过经典和免疫组织化学染色分析了血细胞计数和胎盘微观结构，并观察了受SARS-CoV-2存在影响的胎盘区域。
结果:SARS-CoV-2感染伴随着淋巴细胞数量的减少,血小板的数量和胎盘结构变化的存在，确定淀粉样蛋白沉积物的广泛区域，胎盘梗塞,血管血栓形成,合胞体结,随着胎盘血管密度的降低和位于蜕膜水平的细胞中感染的存在，在合胞体滋养层细胞水平和绒毛膜板细胞水平，在分析的病例中，仍然没有克服这一障碍，也没有引起任何胎儿感染。
结论：这项研究表明，SARS-CoV-2在胎盘中的入侵可以产生明显的结构变化，胎盘血管密度降低，可能对适当的胎儿灌注产生重大影响。此外，蜕膜水平存在免疫反应性，胎盘绒毛，以及绒毛膜板证明病毒可以克服母胎屏障。然而,在分析的病例中，出生时没有胎儿感染，这可能表明局部胎盘因素可能是胎儿的保护性过滤器。
