PDF(Pubmed)
Abstract：
Pericardial cysts (PCs) or pleuropericardial cysts are rare congenital mediastinal lesions with an approximate incidence of one in 100 000 persons. Usually, they are asymptomatic, being incidentally discovered during a routine chest imaging examination or an autopsy exam. The study involved a retrospective evaluation of clinicopathological findings in a 6-year series of PCs, treated in the Clinic of Pulmonary Diseases, Iaşi, Romania. A group of five cases of PCs, four females and one male, were evaluated. All patients displayed different symptoms, such as dyspnea, chest pain, chronic cough, fatigue, palpitation, and epigastric pain. The cystic lesions were located in the right and left cardiophrenic angle, in four cases, and in the central mediastinum in a single case. The lesions had a fluid content and a maximum diameter that ranged between 35 and 95 mm. The microscopic examination of the surgical resection tissues revealed a thin connective tissue wall without any associated smooth muscle cells. The loose connective tissue band was lined by a layer of mesothelial cells with no cellular atypia, which displayed discrete papillary projections, in one case. Although PCs are rare incidental findings, they should be considered in differential diagnoses of mediastinal cysts, especially as they are associated with non-specific symptoms. Furthermore, considering the possibility of development of severe complications, PCs should be thoroughly explored for suitable patients\' management.
摘要：
心包囊肿（PC）或胸膜心包囊肿是罕见的先天性纵隔病变，发病率约为100000人中的1人。通常,他们是无症状的，在常规胸部成像检查或尸检检查中偶然发现。该研究包括对为期6年的PC系列临床病理结果的回顾性评估，在肺病诊所接受治疗，Iaši,罗马尼亚。一组五例PC，四女一男,进行了评估。所有患者都表现出不同的症状，如呼吸困难,胸痛,慢性咳嗽,疲劳,心悸,和上腹痛。囊性病变位于左、右心膈角,在四个案例中，在一个病例中位于中央纵隔。病变的液体含量和最大直径介于35和95毫米之间。手术切除组织的显微镜检查显示薄的结缔组织壁，没有任何相关的平滑肌细胞。疏松的结缔组织带衬有一层间皮细胞，无细胞异型，显示离散的乳头状突起，在一个案例中。尽管PC是罕见的偶然发现，在纵隔囊肿的鉴别诊断中应该考虑它们，尤其是与非特异性症状有关。此外，考虑到发生严重并发症的可能性，应彻底探索PC，以进行合适的患者管理。
