Abstract：
Dietary cadmium (Cd2+) intake is implicated in the pathogenesis of hypertension and anaemia, but there is a paucity of information on the haematological changes in hypertensive conditions. This study, therefore, aims to evaluate the effects of Cd2+ on blood pressure (BP) and haematological indices in the Sprague-Dawley rat model. Three cohorts (n = 10 each) of control and Cd2+-fed male Sprague-Dawley rats were selected. Cd2+-exposed rats received 2.5 or 5 mg/kg b.w. cadmium chloride via gavage thrice-weekly for eight weeks, while control animals received tap water. BP and flow were measured non-invasively from rat tails twice-weekly using a CODA machine, while weights were measured thrice-weekly. Haematological indices were assessed using the Cell-Dyn Emerald Haematology Analyzer. Data were reported as mean ± SEM, and statistically analyzed using One-Way Analysis of Variance. Bonferroni post hoc test was used for multiple comparisons. Cd2+-exposure induced hypertension by significantly (p < 0.05) elevating systolic, diastolic, and mean arterial BPs, pulse pressure, and heart rate (HR), and increased (p < 0.05) blood flow. Mean cell volume (MCV) and haemoglobin (MCH) were significantly (p < 0.05) reduced, and red cell distribution width (RDW) significantly (p < 0.01) increased by exposure to 5 mg/kg b.w. Cd2+. Haemoglobin concentration (MCHC), haematocrit, haemoglobin, red blood cell, platelet, mean platelet volume, and white blood cell counts were unaffected by Cd2+-exposure. Cd2+ induced hypertension, microcytosis, hypochromicity, and anisocytosis without anaemia, which may be precursor to microcytic anaemia and coronary artery disease. This study is important in Cd2+-exposed environments and warrants further investigations.
摘要：
膳食镉（Cd2+）的摄入与高血压和贫血的发病机理有关。但是关于高血压疾病的血液学变化的信息很少。这项研究,因此,目的评价Cd2+对Sprague-Dawley大鼠模型血压和血液学指标的影响。选择对照和Cd2喂养的雄性Sprague-Dawley大鼠的三个队列（每个n=10）。Cd2暴露的大鼠接受2.5或5mg/kgb.w.氯化镉，每周三次，持续八周，而对照动物接受自来水。使用CODA机器每周两次从大鼠尾巴非侵入性地测量BP和流量，而体重每周测量三次。使用Cell-DynEmerald血液学分析仪评估血液学指标。数据报告为平均值±SEM，并使用单向方差分析进行统计分析。Bonferroni事后检验用于多重比较。Cd2+暴露引起的高血压显著（p<0.05）升高收缩压，舒张压,和平均动脉BP，脉压,心率（HR），血流量增加(p<0.05)。平均细胞体积（MCV）和血红蛋白（MCH）显着减少（P<0.05），暴露于5mg/kgb.w.Cd2+后，红细胞分布宽度（RDW）显着增加（p<0.01）。血红蛋白浓度（MCHC），血细胞比容,血红蛋白，红细胞,血小板,平均血小板体积,和白细胞计数不受Cd2暴露的影响。Cd2+诱导的高血压，微胞嘧啶,低色度,和不伴有贫血的红细胞增多症，这可能是小细胞性贫血和冠状动脉疾病的前兆。这项研究在Cd2暴露环境中很重要，值得进一步研究。
