PDF(Pubmed)
Abstract：
Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and intervention of frailty, but the cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation is related to decreased physical function and increased disease risk. Additionally, multiple human and animal studies suggest that inflammation probably plays the largest role in contributing to frailty. Some inflammatory markers have been proposed to predict physical frailty. However, there are still large gaps in knowledge related to the clinical application of these markers in frail patients. Therefore, understanding the biological processes and identifying recognized and reliable markers are urgent and pivotal tasks for geriatricians. In the present review, we broadly summarize the inflammatory markers that may have potential diagnostic and therapeutic use, thereby translating them into health care for older people with frailty in the near future.
摘要：
全球人口老龄化给全世界的卫生保健系统带来了巨大的负担。虚弱与身体储备减少有关，被认为是老年人群不良事件的重要指标。因此,人们对虚弱的早期诊断和干预越来越感兴趣，但是导致虚弱的细胞机制仍然没有完全理解。慢性炎症与身体功能下降和疾病风险增加有关。此外,多项人类和动物研究表明，炎症可能是导致虚弱的最大原因。已经提出了一些炎症标志物来预测身体虚弱。然而,这些标志物在体弱患者中的临床应用方面的知识仍然存在很大的差距。因此,了解生物过程和确定公认的和可靠的标记是紧急和关键的任务，为老年医学。在本次审查中，我们大致总结了可能具有潜在诊断和治疗用途的炎症标志物，从而在不久的将来将其转化为针对虚弱老年人的医疗保健。
