Abstract：
Nuclear Dbf2-related kinase 1 (NDR1) is a nuclear Dbf2-related (NDR) protein kinase family member, which regulates cell functions and participates in cell proliferation and differentiation through kinase activity. NDR1 regulates physiological functions by interacting with different proteins. Protein-protein interactions (PPIs) are crucial for regulating biological processes and controlling cell fate, and as a result, it is beneficial to study the actions of PPIs to elucidate the pathological mechanism of diseases. The previous studies also show that the expression of NDR1 is deregulated in numerous human cancer samples and it needs the context-specific targeting strategies for NDR1. Thus, a comprehensive understanding of the direct interaction between NDR1 and varieties of proteins may provide new insights into cancer therapies. In this review, we summarize recent studies of NDR1 in solid tumors, such as prostate cancer and breast cancer, and explore the mechanism of action of PPIs of NDR1 in tumors.
摘要：
核Dbf2相关激酶1（NDR1）是核Dbf2相关（NDR）蛋白激酶家族成员，它通过激酶活性调节细胞功能并参与细胞增殖和分化。NDR1通过与不同的蛋白质相互作用来调节生理功能。蛋白质-蛋白质相互作用（PPI）对于调节生物过程和控制细胞命运至关重要。结果，研究PPI的作用,有助于阐明疾病的病理机制。先前的研究还表明，NDR1的表达在许多人类癌症样品中失调，并且需要针对NDR1的上下文特异性靶向策略。因此，全面了解NDR1与多种蛋白质之间的直接相互作用可能为癌症治疗提供新的见解.在这次审查中,我们总结了近年来NDR1在实体瘤中的研究，比如前列腺癌和乳腺癌，探讨NDR1PPIs在肿瘤中的作用机制。
