Abstract：
BACKGROUND: To decrease the incidence of major depressive episodes, indicated prevention that targets clinical high-risk individuals with first detectable signs that forecast mental disorder is a highly relevant topic of preventive psychiatry. Still little is known about the prodrome of MDE. The aim of the current study was to identify the occurrence of a clinical high-risk state of depression, its duration and symptom constellation.
METHODS: Seventy-three patients with a diagnosed affective disorder in partial remission were assessed with our newly developed semi-structured extensive clinical instrument, the DEpression Early Prediction-INventory (DEEP-IN). Within DEEP-IN the course of prodromal symptoms was explored by using a life-chart method.
RESULTS: The significant majority of patients (93.2 %) reported a prodromal phase. The mean duration was 7.9 months (SD = 12.5). Within the group with an identified prodromal phase, psychopathological (95.6 %) as well as somatic symptoms (88.2 %) were reported. Somatic symptoms showed a moderate-to-strong effect of sex with higher prevalence in females than in males (97.6 % vs 73.1 %; V = 0.370).
CONCLUSIONS: This feasibility study had only a small sample size.
CONCLUSIONS: The majority of patients with affective disorders reported a clinical prodromal phase with both psychopathological and somatic symptoms that developed months before the onset of the depressive episode. The development of structured instruments for the assessment of depressive risk states is a promising approach for indicated prevention of depression in the future.
METHODS: Seventy-three patients with a diagnosed affective disorder in partial remission were assessed with our newly developed semi-structured extensive clinical instrument, the DEpression Early Prediction-INventory (DEEP-IN). Within DEEP-IN the course of prodromal symptoms was explored by using a life-chart method.
RESULTS: The significant majority of patients (93.2 %) reported a prodromal phase. The mean duration was 7.9 months (SD = 12.5). Within the group with an identified prodromal phase, psychopathological (95.6 %) as well as somatic symptoms (88.2 %) were reported. Somatic symptoms showed a moderate-to-strong effect of sex with higher prevalence in females than in males (97.6 % vs 73.1 %; V = 0.370).
CONCLUSIONS: This feasibility study had only a small sample size.
CONCLUSIONS: The majority of patients with affective disorders reported a clinical prodromal phase with both psychopathological and somatic symptoms that developed months before the onset of the depressive episode. The development of structured instruments for the assessment of depressive risk states is a promising approach for indicated prevention of depression in the future.
摘要：
背景：为了减少重度抑郁发作的发生率，针对具有预测精神障碍的首次可检测体征的临床高危个体的指示预防是预防性精神病学的高度相关主题。对MDE的前体知之甚少。本研究的目的是确定抑郁症的临床高风险状态的发生，它的持续时间和症状星座。
方法：使用我们新开发的半结构化广泛临床仪器评估了73例诊断为部分缓解的情感障碍患者，抑郁症早期预测风险(DEEP-IN)。在DEEP-IN内，通过使用生命图方法探索前驱症状的过程。
结果：绝大多数患者（93.2%）报告为前驱期。平均持续时间为7.9个月（SD=12.5）。在具有确定的前驱阶段的组中，报告了精神病理学（95.6％）和躯体症状（88.2％）。躯体症状表现出中等至强烈的性别效应，女性患病率高于男性（97.6%vs73.1%；V=0.370）。
结论：这项可行性研究的样本量很小。
结论：大多数情感障碍患者报告的临床前驱阶段有精神病理学和躯体症状，在抑郁发作前几个月出现。开发用于评估抑郁风险状态的结构化工具是未来预防抑郁的有希望的方法。
方法：使用我们新开发的半结构化广泛临床仪器评估了73例诊断为部分缓解的情感障碍患者，抑郁症早期预测风险(DEEP-IN)。在DEEP-IN内，通过使用生命图方法探索前驱症状的过程。
结果：绝大多数患者（93.2%）报告为前驱期。平均持续时间为7.9个月（SD=12.5）。在具有确定的前驱阶段的组中，报告了精神病理学（95.6％）和躯体症状（88.2％）。躯体症状表现出中等至强烈的性别效应，女性患病率高于男性（97.6%vs73.1%；V=0.370）。
结论：这项可行性研究的样本量很小。
结论：大多数情感障碍患者报告的临床前驱阶段有精神病理学和躯体症状，在抑郁发作前几个月出现。开发用于评估抑郁风险状态的结构化工具是未来预防抑郁的有希望的方法。
