Abstract：
Ischemia-reperfusion injury (IRI) represents a prevalent pathological phenomenon. Traditional treatment approaches primarily aim at restoring blood supply to ischemic organs, disregarding the consequent damage caused by IRI. Belonging to the class of protopanaxadiol ginsenosides that are found in Panax ginseng, ginsenoside Rd (GSRd) demonstrates notable safety alongside a diverse range of biological functions. Its active components exhibit diverse pharmacological effects, encompassing anti-inflammatory, anti-tumor, neuroprotective, cardiovascular-protective, and immune-regulatory properties, making it a promising candidate for addressing multiple medical conditions. GSRd shields against I/R injury by employing crucial cellular mechanisms, including the attenuation of oxidative stress, reduction of inflammation, promotion of cell survival signaling pathways, and inhibition of apoptotic pathways. Additionally, GSRd regulates mitochondrial function, maintains calcium homeostasis, and modulates the expression of genes involved in I/R injury. This review seeks to consolidate the pharmacological mechanism of action of GSRd within the context of IRI. Our objective is to contribute to the advancement of GSRd-related pharmaceuticals and provide novel insights for clinicians involved in developing IRI treatment strategies.
摘要：
缺血再灌注损伤（IRI）是一种普遍的病理现象。传统的治疗方法主要旨在恢复缺血器官的血液供应，无视IRI造成的损害。属于人参中发现的原人参二醇人参皂甙类，人参皂苷Rd（GSRd）显示出显着的安全性以及各种生物学功能。其活性成分表现出不同的药理作用，包括抗炎，抗肿瘤，神经保护,心血管保护，和免疫调节特性，使其成为解决多种疾病的有希望的候选人。GSRd通过采用关键的细胞机制来保护I/R损伤，包括氧化应激的衰减，减少炎症，促进细胞存活信号通路，和抑制凋亡途径。此外,GSRd调节线粒体功能，保持钙稳态，并调节参与I/R损伤的基因的表达。这篇综述旨在巩固IRI背景下GSRd的药理作用机制。我们的目标是促进GSRd相关药物的发展，并为参与制定IRI治疗策略的临床医生提供新的见解。
