Abstract：
BACKGROUND: Brain metastasis is rare in nasopharyngeal carcinoma (NPC), with only anecdotal cases reported. Conducting a systematic study is crucial for improving the management of these patients.
METHODS: Forty-one patients with brain metastasis were retrospectively included between February 2000 and February 2023. The clinical characteristics and treatment information of patients were analyzed. Overall survival (OS) was estimated by Kaplan-Meier survival analysis, and Cox proportional hazard regression analysis was performed to explore prognostic factors.
RESULTS: The median OS for patients was 11.2 months, with a 3-year OS rate of 16.3%. The number of extracranial metastatic organs (HR = 5.533, P = 0.041) and the response of extracranial tumors to treatment (HR = 0.079, P = 0.003) were independent prognostic factors in the cohort.
CONCLUSIONS: Brain metastasis in NPC is a devastating condition that commonly occurs through hematogenous dissemination. Systemic therapy remains fundamental treatment, while local therapy for brain metastases may further improve survival in selected patients.
METHODS: Forty-one patients with brain metastasis were retrospectively included between February 2000 and February 2023. The clinical characteristics and treatment information of patients were analyzed. Overall survival (OS) was estimated by Kaplan-Meier survival analysis, and Cox proportional hazard regression analysis was performed to explore prognostic factors.
RESULTS: The median OS for patients was 11.2 months, with a 3-year OS rate of 16.3%. The number of extracranial metastatic organs (HR = 5.533, P = 0.041) and the response of extracranial tumors to treatment (HR = 0.079, P = 0.003) were independent prognostic factors in the cohort.
CONCLUSIONS: Brain metastasis in NPC is a devastating condition that commonly occurs through hematogenous dissemination. Systemic therapy remains fundamental treatment, while local therapy for brain metastases may further improve survival in selected patients.
摘要：
背景：脑转移在鼻咽癌（NPC）中很少见，只有轶事病例报告。进行系统的研究对于改善这些患者的管理至关重要。
方法：回顾性纳入2000年2月至2023年2月的41例脑转移患者。分析患者的临床特点及治疗情况。总生存期（OS）通过Kaplan-Meier生存分析估计，并进行Cox比例风险回归分析以探讨预后因素。
结果：患者的中位OS为11.2个月，3年OS率为16.3%。颅外转移器官数量（HR=5.533，P=0.041）和颅外肿瘤对治疗的反应（HR=0.079，P=0.003）是影响预后的独立因素。
结论：NPC的脑转移是一种破坏性疾病，通常通过血行播散发生。全身治疗仍然是基本治疗，而脑转移的局部治疗可以进一步提高部分患者的生存率。
方法：回顾性纳入2000年2月至2023年2月的41例脑转移患者。分析患者的临床特点及治疗情况。总生存期（OS）通过Kaplan-Meier生存分析估计，并进行Cox比例风险回归分析以探讨预后因素。
结果：患者的中位OS为11.2个月，3年OS率为16.3%。颅外转移器官数量（HR=5.533，P=0.041）和颅外肿瘤对治疗的反应（HR=0.079，P=0.003）是影响预后的独立因素。
结论：NPC的脑转移是一种破坏性疾病，通常通过血行播散发生。全身治疗仍然是基本治疗，而脑转移的局部治疗可以进一步提高部分患者的生存率。
