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Abstract：
UNASSIGNED: The aim of this study was to identify the prevalent pathogens that caused neonatal septicemia and their corresponding antimicrobial sensitivities in the neonatal intensive care unit (NICU) in the West Bank.
UNASSIGNED: In this retrospective study, we extracted records of neonates with suspected neonatal sepsis (NS) admitted to three NICUs in the West Bank between 2019 and 2021 from the Ministry of Health\'s electronic database.
UNASSIGNED: Out of 6090 suspected episodes of NS, 884 tested positive for blood cultures, and 554 were primary cases; 59.5% were male, 26.6% were preterm, and 52.7% were aged 0-7 days. Moreover, 29% of 884 positive cultures were contributed by multidrug-resistant organisms (MDRO). Only 14.6% of episodes aligned with both Word Health Organization-recommended antibiotic regimens, 5.2% matched with one regimen, and 80.3% did not match either regimen. Specifically, 19.6% of cases matched with ampicillin-gentamicin, and 14.7% matched with ampicillin-cefotaxime. The likelihood of a match between early-onset sepsis and empiric antibiotic regimens was greater than late-onset sepsis (odds ratio = 2.549, [95% confidence interval: 1.276-5.092]). MDRO was more likely than non-MDRO to match with one antibiotic regimen (odds ratio = 4.142 [95% confidence interval: 1.913-8.966]).
UNASSIGNED: There is an alarming prevalence of MDRO among Palestinian neonates in the NICU of the West Bank. The study highlights the urgent need for implementation of effective infection control measures and antimicrobial stewardship programs in the NICUs of hospitals in the West Bank to reduce the prevalence of MDRO and improve neonatal health outcomes.
UNASSIGNED: In this retrospective study, we extracted records of neonates with suspected neonatal sepsis (NS) admitted to three NICUs in the West Bank between 2019 and 2021 from the Ministry of Health\'s electronic database.
UNASSIGNED: Out of 6090 suspected episodes of NS, 884 tested positive for blood cultures, and 554 were primary cases; 59.5% were male, 26.6% were preterm, and 52.7% were aged 0-7 days. Moreover, 29% of 884 positive cultures were contributed by multidrug-resistant organisms (MDRO). Only 14.6% of episodes aligned with both Word Health Organization-recommended antibiotic regimens, 5.2% matched with one regimen, and 80.3% did not match either regimen. Specifically, 19.6% of cases matched with ampicillin-gentamicin, and 14.7% matched with ampicillin-cefotaxime. The likelihood of a match between early-onset sepsis and empiric antibiotic regimens was greater than late-onset sepsis (odds ratio = 2.549, [95% confidence interval: 1.276-5.092]). MDRO was more likely than non-MDRO to match with one antibiotic regimen (odds ratio = 4.142 [95% confidence interval: 1.913-8.966]).
UNASSIGNED: There is an alarming prevalence of MDRO among Palestinian neonates in the NICU of the West Bank. The study highlights the urgent need for implementation of effective infection control measures and antimicrobial stewardship programs in the NICUs of hospitals in the West Bank to reduce the prevalence of MDRO and improve neonatal health outcomes.
摘要：
■这项研究的目的是在西岸的新生儿重症监护病房（NICU）中确定引起新生儿败血症的流行病原体及其相应的抗菌敏感性。
■在这项回顾性研究中，我们从卫生部的电子数据库中提取了2019年至2021年西岸3个NICU收治的疑似新生儿败血症(NS)新生儿的记录.
■在6090次疑似NS发作中，884人血培养检测呈阳性,554例为原发性病例；59.5%为男性，26.6%是早产,52.7%年龄为0-7天。此外，884个阳性培养物中有29％是由耐多药生物（MDRO）贡献的。只有14.6％的发作与世界卫生组织推荐的两种抗生素方案一致，5.2%与一种方案相匹配，80.3%与两种方案均不匹配。具体来说,19.6%的病例与氨苄西林-庆大霉素相匹配,14.7%与氨苄青霉素-头孢噻肟匹配。早发性败血症和经验性抗生素方案之间匹配的可能性大于晚发性败血症（比值比=2.549，[95％置信区间：1.276-5.092]）。MDRO比非MDRO更可能与一种抗生素方案匹配（比值比=4.142[95％置信区间：1.913-8.966]）。
■在西岸NICU的巴勒斯坦新生儿中，MDRO的患病率令人震惊。该研究强调，迫切需要在西岸医院的NICU中实施有效的感染控制措施和抗菌药物管理计划，以降低MDRO的患病率并改善新生儿健康结局。
■在这项回顾性研究中，我们从卫生部的电子数据库中提取了2019年至2021年西岸3个NICU收治的疑似新生儿败血症(NS)新生儿的记录.
■在6090次疑似NS发作中，884人血培养检测呈阳性,554例为原发性病例；59.5%为男性，26.6%是早产,52.7%年龄为0-7天。此外，884个阳性培养物中有29％是由耐多药生物（MDRO）贡献的。只有14.6％的发作与世界卫生组织推荐的两种抗生素方案一致，5.2%与一种方案相匹配，80.3%与两种方案均不匹配。具体来说,19.6%的病例与氨苄西林-庆大霉素相匹配,14.7%与氨苄青霉素-头孢噻肟匹配。早发性败血症和经验性抗生素方案之间匹配的可能性大于晚发性败血症（比值比=2.549，[95％置信区间：1.276-5.092]）。MDRO比非MDRO更可能与一种抗生素方案匹配（比值比=4.142[95％置信区间：1.913-8.966]）。
■在西岸NICU的巴勒斯坦新生儿中，MDRO的患病率令人震惊。该研究强调，迫切需要在西岸医院的NICU中实施有效的感染控制措施和抗菌药物管理计划，以降低MDRO的患病率并改善新生儿健康结局。
