UNASSIGNED: A retrospective review was conducted of the medical records of 613 patients who underwent intraoperative pCEA sampling and lung resection for non-small cell lung cancer. Of these, 390 individuals with clinical stage I adenocarcinoma and tumors ≤30 mm were included. Based on computed tomography findings, these patients were divided into pleural contact (n=186) and non-pleural contact (n=204) groups. A receiver operating characteristic (ROC) curve was constructed to analyze the association between pCEA and SUVmax in relation to VPI. Additionally, logistic regression analysis was performed to evaluate risk factors for VPI in each group.
UNASSIGNED: ROC curve analysis revealed that pCEA level greater than 2.565 ng/mL (area under the curve [AUC]=0.751) and SUVmax above 4.25 (AUC=0.801) were highly predictive of VPI in patients exhibiting pleural contact. Based on multivariable analysis, pCEA (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.14-7.87; p=0.026) and SUVmax (OR, 5.25; 95% CI, 1.90-14.50; p=0.001) were significant risk factors for VPI in the pleural contact group.
UNASSIGNED: In patients with clinical stage I lung adenocarcinoma exhibiting pleural contact, pCEA and SUVmax are potential predictive indicators of VPI. These markers may be helpful in planning for lung cancer surgery.
■对613例非小细胞肺癌术中接受pCEA采样和肺切除术的患者的病历进行了回顾性分析。其中,包括390例临床I期腺癌和肿瘤≤30mm的个体。根据计算机断层扫描的结果,这些患者被分为胸膜接触组(n=186)和非胸膜接触组(n=204)。构建受试者工作特征(ROC)曲线以分析pCEA与SUVmax之间与VPI的关系。此外,采用logistic回归分析评价各组VPI的危险因素。
■ROC曲线分析显示,pCEA水平高于2.565ng/mL(曲线下面积[AUC]=0.751)和SUVmax高于4.25(AUC=0.801)是胸膜接触患者VPI的高度预测。基于多变量分析,pCEA(赔率比[OR],3.00;95%置信区间[CI],1.14-7.87;p=0.026)和SUVmax(OR,5.25;95%CI,1.90-14.50;p=0.001)是胸膜接触组中VPI的重要危险因素。
■在表现为胸膜接触的临床I期肺腺癌患者中,pCEA和SUVmax是VPI的潜在预测指标。这些标记物可能有助于肺癌手术的计划。