Abstract：
UNASSIGNED: Cutaneous leishmaniasis (CL) is one of the main causes of vector-born diseases in younger population. To evaluate the association of environmental health factors on the odds of CL incidence, a case-control study was conducted in northeastern Iran.
UNASSIGNED: This study was conducted within 2020-2021 based on individual and household data from a tertiary referral center. Cases were patients diagnosed with CL by PCR method; controls were selected among the patients\' relatives, and information was obtained from a health registry system. Demographic and socioeconomic data of 1871 subjects, included age, sex, household information and environmental health factors. Multivariable models with environmental factors in various conditions and CL were separately fit by univariate and mixed multiple unconditional logistic regression.
UNASSIGNED: Participants included 617 cases (mean [SD] age, 13.62[13.72] years; 58.20% male) and 1264 controls (mean [SD] age, 16.45[15.44] years; 50.40% male). Results revealed that the use of well-water sources compared to surface water is significantly associated with CL (odds ratio [OR]=0.204; 95%CI, 0.13-0.33;P<0.001). Muddy houses, ruined buildings or wastelands and stagnant water, canals and rivers near the houses were also associated with CL (OR=3.85; 95%CI, 1.66-8.89; P=.002; OR=2.47; 95%CI, 1.76-3.47; P<.001). Besides, existence of pine tree was found to be a risk factor (OR=3.25; 95%CI, 2.12-4.99; P<.001) and similarly for the use of waste collection system (OR=4.43; 95%CI, 3.32-7.51; P<.001).
UNASSIGNED: Environmental factors related to houses were significantly associated with CL and may represent the modifiable risk factors of CL disease.
UNASSIGNED: This study was conducted within 2020-2021 based on individual and household data from a tertiary referral center. Cases were patients diagnosed with CL by PCR method; controls were selected among the patients\' relatives, and information was obtained from a health registry system. Demographic and socioeconomic data of 1871 subjects, included age, sex, household information and environmental health factors. Multivariable models with environmental factors in various conditions and CL were separately fit by univariate and mixed multiple unconditional logistic regression.
UNASSIGNED: Participants included 617 cases (mean [SD] age, 13.62[13.72] years; 58.20% male) and 1264 controls (mean [SD] age, 16.45[15.44] years; 50.40% male). Results revealed that the use of well-water sources compared to surface water is significantly associated with CL (odds ratio [OR]=0.204; 95%CI, 0.13-0.33;P<0.001). Muddy houses, ruined buildings or wastelands and stagnant water, canals and rivers near the houses were also associated with CL (OR=3.85; 95%CI, 1.66-8.89; P=.002; OR=2.47; 95%CI, 1.76-3.47; P<.001). Besides, existence of pine tree was found to be a risk factor (OR=3.25; 95%CI, 2.12-4.99; P<.001) and similarly for the use of waste collection system (OR=4.43; 95%CI, 3.32-7.51; P<.001).
UNASSIGNED: Environmental factors related to houses were significantly associated with CL and may represent the modifiable risk factors of CL disease.
摘要：
■皮肤利什曼病（CL）是年轻人群中媒介传播疾病的主要原因之一。为了评估环境健康因素与CL发病率的关系，在伊朗东北部进行了一项病例对照研究.
■这项研究是在2020-2021年期间根据三级转诊中心的个人和家庭数据进行的。病例为通过PCR方法诊断为CL的患者；在患者亲属中选择对照，信息是从健康登记系统获得的。1871个科目的人口和社会经济数据，包括年龄,性别,家庭信息和环境健康因素。在各种条件下具有环境因素的多变量模型和CL分别通过单变量和混合多条件逻辑回归拟合。
■参与者包括617例（平均[SD]年龄，13.62[13.72]岁；58.20%男性)和1264名对照(平均[SD]年龄，16.45[15.44]岁；50.40%男性）。结果表明，与地表水相比，井水水源的使用与CL显着相关（比值比[OR]=0.204；95CI，0.13-0.33；P<0.001）。泥泞的房子,毁坏的建筑物或荒地和死水，房屋附近的运河和河流也与CL相关(OR=3.85;95CI,1.66-8.89;P=.002;OR=2.47;95CI,1.76-3.47;P<.001)。此外,发现松树的存在是一个危险因素(OR=3.25;95CI,2.12-4.99;P<.001),废物收集系统的使用也是如此(OR=4.43;95CI,3.32-7.51;P<.001)。
■与房屋相关的环境因素与CL显著相关，并且可能代表CL疾病的可改变的危险因素。
■这项研究是在2020-2021年期间根据三级转诊中心的个人和家庭数据进行的。病例为通过PCR方法诊断为CL的患者；在患者亲属中选择对照，信息是从健康登记系统获得的。1871个科目的人口和社会经济数据，包括年龄,性别,家庭信息和环境健康因素。在各种条件下具有环境因素的多变量模型和CL分别通过单变量和混合多条件逻辑回归拟合。
■参与者包括617例（平均[SD]年龄，13.62[13.72]岁；58.20%男性)和1264名对照(平均[SD]年龄，16.45[15.44]岁；50.40%男性）。结果表明，与地表水相比，井水水源的使用与CL显着相关（比值比[OR]=0.204；95CI，0.13-0.33；P<0.001）。泥泞的房子,毁坏的建筑物或荒地和死水，房屋附近的运河和河流也与CL相关(OR=3.85;95CI,1.66-8.89;P=.002;OR=2.47;95CI,1.76-3.47;P<.001)。此外,发现松树的存在是一个危险因素(OR=3.25;95CI,2.12-4.99;P<.001),废物收集系统的使用也是如此(OR=4.43;95CI,3.32-7.51;P<.001)。
■与房屋相关的环境因素与CL显著相关，并且可能代表CL疾病的可改变的危险因素。
