PDF(Pubmed)
Abstract：
The pathogenesis of venous thromboembolism in multiple myeloma is still poorly understood because multiple factors are involved. In particular, the increase in whole blood viscosity has a key role and, therefore, we performed an evaluation of some hemorheological determinants in multiple myeloma patients, putting them in relation to the thrombotic risk, with the aim to evaluate if an alteration of the hemorheological pattern was associated with a higher thrombotic risk. We performed an observational retrospective cohort study with data collected from January 2017 to September 2022. In a group of 190 patients with newly diagnosed multiple myeloma, we have examined the trend of calculated blood viscosity according to the Merrill formula, and we stratified the patients for the thrombotic risk in accordance with the IMWG/NCCN guidelines and with IMPEDE VTE score. Using the thrombotic risk stratification proposed by IMWG/NCCN any variation in calculated blood viscosity is evident, while, with the IMPEDE VTE score, we observed an increase in calculated blood viscosity in patients with \"intermediate + high\" risk. The calculated blood viscosity is higher in subjects presenting an \"intermediate + high\" thrombotic risk according to the IMPEDE VTE score. This association could therefore lay the groundwork for further research with the aim to confirm the role of hemorheological pattern in MM-related thrombotic risk.
摘要：
多发性骨髓瘤中静脉血栓栓塞的发病机制仍然知之甚少，因为涉及多种因素。特别是,全血黏度的增加具有关键作用,因此,我们对多发性骨髓瘤患者的一些血液流变学决定因素进行了评估，将它们与血栓形成风险联系起来，目的是评估血液流变学模式的改变是否与较高的血栓形成风险相关。我们进行了一项观察性回顾性队列研究，收集了2017年1月至2022年9月的数据。在一组190例新诊断的多发性骨髓瘤患者中，我们研究了根据美林公式计算的血液粘度的趋势，我们根据IMWG/NCCN指南和IMPEDEVTE评分对患者的血栓风险进行了分层.使用IMWG/NCCN提出的血栓风险分层，计算的血液粘度的任何变化都是明显的，while,随着IMPEDEVTE得分，我们观察到“中度+高度”风险患者的计算血液粘度增加。根据IMPEDEVTE评分，呈现“中等+高”血栓形成风险的受试者计算的血液粘度较高。因此，这种关联可以为进一步研究奠定基础，目的是确认血液流变学模式在MM相关血栓形成风险中的作用。
