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Abstract：
Accumulating evidence has indicated that oxidative stress (OS) and matrix metalloproteinase-9 (MMP-9) may contribute to the mechanism of schizophrenia. In the present study, we aimed to evaluate the associations of OS parameters and MMP-9 levels with psychopathological symptoms in male chronic schizophrenia patients.
This study was an observational, cross-sectional, retrospective case-control study. Plasma hydrogen peroxide (H2O2), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), serum matrix metalloproteinase-9 (MMP-9), and tissue inhibitors of metalloproteinases-1 (TIMP-1) levels were assayed in 80 male patients with chronic schizophrenia and 80 matched healthy controls. Schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS). Multivariate regression was used to analyze relationships between OS parameters and MMP-9, and clinical symptoms.
Our results demonstrated that levels of antioxidant enzymes, SOD, GSH-Px, H2O2, and MDA were significantly decreased, whereas CAT and MMP-9 levels were increased in patients with schizophrenia, when compared with healthy controls (all P < 0.05). In schizophrenia patients, correlation analyses showed that H2O2 levels were significantly and positively correlated with PANSS positive scores, CAT and MDA levels were significant negatively correlated with PANSS negative scores and PANSS total scores, and MDA levels were significantly positively correlated with MMP-9 levels (all P < 0.05). However, we did not find that MMP-9 played an interaction role between OS parameters and PANSS total scores and subscales scores (all P > 0.05).
Our results showed that alterations of plasma OS parameters in male patients with chronic schizophrenia were associated with psychopathology and MMP-9, suggesting that OS and neuroinflammation may play important role in the mechanism of schizophrenia.
This study was an observational, cross-sectional, retrospective case-control study. Plasma hydrogen peroxide (H2O2), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), serum matrix metalloproteinase-9 (MMP-9), and tissue inhibitors of metalloproteinases-1 (TIMP-1) levels were assayed in 80 male patients with chronic schizophrenia and 80 matched healthy controls. Schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS). Multivariate regression was used to analyze relationships between OS parameters and MMP-9, and clinical symptoms.
Our results demonstrated that levels of antioxidant enzymes, SOD, GSH-Px, H2O2, and MDA were significantly decreased, whereas CAT and MMP-9 levels were increased in patients with schizophrenia, when compared with healthy controls (all P < 0.05). In schizophrenia patients, correlation analyses showed that H2O2 levels were significantly and positively correlated with PANSS positive scores, CAT and MDA levels were significant negatively correlated with PANSS negative scores and PANSS total scores, and MDA levels were significantly positively correlated with MMP-9 levels (all P < 0.05). However, we did not find that MMP-9 played an interaction role between OS parameters and PANSS total scores and subscales scores (all P > 0.05).
Our results showed that alterations of plasma OS parameters in male patients with chronic schizophrenia were associated with psychopathology and MMP-9, suggesting that OS and neuroinflammation may play important role in the mechanism of schizophrenia.
摘要：
背景：越来越多的证据表明，氧化应激（OS）和基质金属蛋白酶-9（MMP-9）可能与精神分裂症的发病机制有关。在本研究中,我们旨在评估男性慢性精神分裂症患者OS参数和MMP-9水平与精神病理症状的相关性.
方法：这项研究是一项观察性的，横截面,回顾性病例对照研究。等离子体过氧化氢（H2O2），丙二醛（MDA），超氧化物歧化酶（SOD），过氧化氢酶(CAT),谷胱甘肽过氧化物酶（GSH-Px），血清基质金属蛋白酶-9(MMP-9),在80例男性慢性精神分裂症患者和80例匹配的健康对照中测定了金属蛋白酶-1（TIMP-1）的组织抑制剂水平。精神分裂症症状采用阳性和阴性症状量表（PANSS）进行评估。采用多因素回归分析OS参数与MMP-9及临床症状的关系。
结果：我们的结果表明，抗氧化酶的水平，SOD,GSH-Px,H2O2和MDA显著下降，而精神分裂症患者的CAT和MMP-9水平升高，与健康对照组相比（均P<0.05）。在精神分裂症患者中，相关分析表明，H2O2水平与PANSS阳性评分呈显著正相关，CAT和MDA水平与PANSS阴性评分和PANSS总分呈显著负相关,MDA水平与MMP-9水平呈显著正相关(均P<0.05)。然而,我们没有发现MMP-9在OS参数与PANSS总分和分量表评分之间起交互作用(均P>0.05)。
结论：我们的结果表明，男性慢性精神分裂症患者血浆OS参数的改变与精神病理学和MMP-9有关，提示OS和神经炎症可能在精神分裂症的发病机制中起重要作用。
方法：这项研究是一项观察性的，横截面,回顾性病例对照研究。等离子体过氧化氢（H2O2），丙二醛（MDA），超氧化物歧化酶（SOD），过氧化氢酶(CAT),谷胱甘肽过氧化物酶（GSH-Px），血清基质金属蛋白酶-9(MMP-9),在80例男性慢性精神分裂症患者和80例匹配的健康对照中测定了金属蛋白酶-1（TIMP-1）的组织抑制剂水平。精神分裂症症状采用阳性和阴性症状量表（PANSS）进行评估。采用多因素回归分析OS参数与MMP-9及临床症状的关系。
结果：我们的结果表明，抗氧化酶的水平，SOD,GSH-Px,H2O2和MDA显著下降，而精神分裂症患者的CAT和MMP-9水平升高，与健康对照组相比（均P<0.05）。在精神分裂症患者中，相关分析表明，H2O2水平与PANSS阳性评分呈显著正相关，CAT和MDA水平与PANSS阴性评分和PANSS总分呈显著负相关,MDA水平与MMP-9水平呈显著正相关(均P<0.05)。然而,我们没有发现MMP-9在OS参数与PANSS总分和分量表评分之间起交互作用(均P>0.05)。
结论：我们的结果表明，男性慢性精神分裂症患者血浆OS参数的改变与精神病理学和MMP-9有关，提示OS和神经炎症可能在精神分裂症的发病机制中起重要作用。
