Abstract：
In the Czech Republic, it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester up until the 49th day of secondary amenorrhea. The aim of the study is to analyse the significance of serum/urine human chorionic gonadotropin (hCG) assessment and ultrasound (US) examination in pregnancy diagnosis and MToP follow-up.
In 2017-2018, MToP was carried out in a total of 109 women by administering a combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally). Serum/urine (LSUP - low sensitivity urine pregnancy test) hCG assessment and US examination were performed at pregnancy diagnosis and MToP follow-up.
At pregnancy diagnosis, there was a positive and medium strong correlation between serum hCG and size of the gestational sac - GS (R = 0.711; P 1,000 IU/L and LSUP test was always positive). In 5.5% of women (6/109), a subsequent surgical intervention was carried out including those with ongoing pregnancy (N = 5); missed abortion (N = 1) was treated by additional misoprostol, where surgical intervention was not necessary.
At pregnancy diagnosis, there is a positive and medium strong correlation between serum hCG and CRL. In MToP follow-up, a negative LSUP test enables reliable exclusion of ongoing pregnancy and missed abortion. In case of a positive LSUP test, US examination should be performed; however, surgical intervention should not be indicated solely on the basis of uterine cavity dilatation.
In 2017-2018, MToP was carried out in a total of 109 women by administering a combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally). Serum/urine (LSUP - low sensitivity urine pregnancy test) hCG assessment and US examination were performed at pregnancy diagnosis and MToP follow-up.
At pregnancy diagnosis, there was a positive and medium strong correlation between serum hCG and size of the gestational sac - GS (R = 0.711; P 1,000 IU/L and LSUP test was always positive). In 5.5% of women (6/109), a subsequent surgical intervention was carried out including those with ongoing pregnancy (N = 5); missed abortion (N = 1) was treated by additional misoprostol, where surgical intervention was not necessary.
At pregnancy diagnosis, there is a positive and medium strong correlation between serum hCG and CRL. In MToP follow-up, a negative LSUP test enables reliable exclusion of ongoing pregnancy and missed abortion. In case of a positive LSUP test, US examination should be performed; however, surgical intervention should not be indicated solely on the basis of uterine cavity dilatation.
摘要：
在捷克共和国,这是可能的，在妊娠早期进行医学终止妊娠（MToP），直到继发性闭经的第49天。该研究的目的是分析血清/尿液人绒毛膜促性腺激素（hCG）评估和超声（US）检查在妊娠诊断和MToP随访中的意义。
在2017-2018年，通过给予米非司酮（600mg口服）和米索前列醇（400mcg口服）的组合，对总共109名女性进行了MToP。在妊娠诊断和MToP随访时进行血清/尿液（LSUP-低敏感性尿液妊娠试验）hCG评估和US检查。
在诊断妊娠时，血清hCG与孕囊-GS大小呈正相关,且呈中等相关性(R=0.711;P1,000IU/L,LSUP检验始终为阳性).5.5%的妇女(6/109)，随后进行了手术干预，包括那些正在怀孕的人（N=5）;错过流产（N=1）通过额外的米索前列醇治疗，不需要手术干预的地方。
在诊断妊娠时，血清hCG与CRL呈正相关，呈中等强相关。在MToP随访中，LSUP检测阴性可以可靠地排除正在进行的妊娠和稽留流产.如果LSUP测试呈阳性，应该进行美国检查；然而，手术干预不应仅仅基于子宫腔扩张。
在2017-2018年，通过给予米非司酮（600mg口服）和米索前列醇（400mcg口服）的组合，对总共109名女性进行了MToP。在妊娠诊断和MToP随访时进行血清/尿液（LSUP-低敏感性尿液妊娠试验）hCG评估和US检查。
在诊断妊娠时，血清hCG与孕囊-GS大小呈正相关,且呈中等相关性(R=0.711;P1,000IU/L,LSUP检验始终为阳性).5.5%的妇女(6/109)，随后进行了手术干预，包括那些正在怀孕的人（N=5）;错过流产（N=1）通过额外的米索前列醇治疗，不需要手术干预的地方。
在诊断妊娠时，血清hCG与CRL呈正相关，呈中等强相关。在MToP随访中，LSUP检测阴性可以可靠地排除正在进行的妊娠和稽留流产.如果LSUP测试呈阳性，应该进行美国检查；然而，手术干预不应仅仅基于子宫腔扩张。
