PDF(Pubmed)
Abstract：
Parrot Bornavirus (PaBV) has been reported to cause indigestion and other wasting symptoms such as weight loss and lethargy. The pathogenesis of PaBV has yet to be fully elucidated. This study reports PaBV infections in South Korea and suggests a trend in the genetic information gathered from clinical cases. A total of 487 birds with or without clinical symptoms were tested for bornavirus. Twelve of 361 asymptomatic birds tested positive for bornavirus, while 15 of 126 birds with various symptoms tested positive. A segment of approximately 1,540 bps including the N, X, P and M proteins were obtained from 23 of the positive strains and analyzed with other strains found on GenBank that had clinical information. PaBV was type 2 and 4 in South Korea, and certain amino acid sequences showed a difference between symptom presenting animals and asymptomatic animals in the X protein and P protein. When considering that some asymptomatic cases may have been latent infections at the time of examination, it is plausible these trends may grow stronger with time. Majority of PaBV was type 4 in South Korea. If these trends are confirmed, diagnosis of potentially pathogenic PaBVs in a clinical manner will be possible during the early stages of infection.
摘要：
据报道，鹦鹉博纳病毒（PaBV）会导致消化不良和其他消瘦症状，例如体重减轻和嗜睡。PaBV的发病机制尚未完全阐明。这项研究报告了韩国的PaBV感染，并暗示了从临床病例中收集的遗传信息的趋势。总共对487只具有或没有临床症状的禽鸟进行了博尔纳病毒的测试。361只无症状禽鸟中,有12只检测出博尔纳病毒阳性,在126只出现各种症状的禽鸟中，有15只测试呈阳性。包括N在内的大约1,540bps的段，X,从23个阳性菌株中获得P和M蛋白，并与GenBank上发现的具有临床信息的其他菌株进行分析。PaBV在韩国是2型和4型，某些氨基酸序列在X蛋白和P蛋白方面显示出症状表现动物与无症状动物之间的差异。当考虑到一些无症状病例在检查时可能是潜伏感染时，这些趋势可能会随着时间的推移而变得更加强大。在韩国，大多数PaBV是4型。如果这些趋势得到证实，在感染的早期阶段，以临床方式诊断潜在致病性PaBVs是可能的。
