PDF(Pubmed)
Abstract：
Anti-IgLON5 disease shows various neurological manifestations, of which dysautonomia is one of the major symptoms and is rarely improved by immunotherapy. We herein report a patient with anti-IgLON5 disease who showed several autonomic failures, including vocal cord palsy for four months. The patient presented with cognitive impairments, bulbar symptoms accompanied by myorhythmia in the pharynx and tongue, cerebellar ataxia with tremor, motor neuron symptoms in the limbs, gastrointestinal dysfunction, orthostatic hypotension, non-rapid eye movement sleep disorder on polysomnography, and severe vocal cord palsy. Combined immunotherapy improved his symptoms, including vocal cord palsy, suggesting that combined immunotherapy might improve dysautonomia in anti-IgLON5 disease.
摘要：
抗IgLON5疾病显示各种神经系统表现，其中自主神经失调是主要症状之一，很少通过免疫疗法得到改善。我们在此报告了一名患有抗IgLON5疾病的患者，他表现出几种自主神经功能衰竭，包括四个月的声带麻痹.患者出现认知障碍，延髓症状伴有咽部和舌头的肌节律，小脑共济失调伴震颤，四肢运动神经元症状，胃肠功能障碍,直立性低血压,多导睡眠图上的非快速眼动睡眠障碍，和严重的声带麻痹.联合免疫疗法改善了他的症状，包括声带麻痹,提示联合免疫疗法可能改善抗IgLON5疾病中的自主神经失调。
