Abstract：
A middle-aged woman presented with hypertensive emergency after corticosteroid treatment for Sjögren syndrome-associated multiple mononeuropathy with suspected systemic sclerosis. Hypertensive heart failure with hyperreninemia improved with antihypertensives, including aliskiren; however, she became hemodialysis-dependent. Clinical findings and biopsy-proven thrombotic microangiopathy indicated conditions resembling scleroderma renal crisis (SRC). Severe hypertension and heart failure with hyperreninemia occurred after stopping aliskiren for hypotension due to diverticular bleeding, which improved after the reintroduction of aliskiren. Aliskiren appears to be effective in managing hypertensive heart failure in patients with SRC. Nevertheless, hemodialysis remained necessary in our case, and whether or not aliskiren can restore the renal function is unclear.
摘要：
一名中年妇女在接受Sjögren综合征相关的多发性单神经病伴疑似系统性硬化症的皮质类固醇治疗后出现高血压急症。抗高血压药改善了高血压心力衰竭伴高肾素血症，包括阿利斯基伦；然而，她开始依赖血液透析.临床发现和活检证实的血栓性微血管病变表明类似硬皮病肾危象（SRC）。因憩室出血引起的低血压停药阿利吉仑后发生严重高血压和心力衰竭伴高肾素血症，重新引入阿利斯基伦后有所改善。阿利吉仑似乎可有效治疗SRC患者的高血压心力衰竭。然而，在我们的情况下，血液透析仍然是必要的，阿利吉仑能否恢复肾功能尚不清楚。
