Abstract：
Wound dressings act as a physical barrier between the wound site and the external environment, preventing additional harm; choosing suitable wound dressings is essential for the healing process. Polysaccharide biopolymers have demonstrated encouraging findings and therapeutic prospects in recent decades about wound therapy. Additionally, polysaccharides have bioactive qualities like anti-inflammatory, antibacterial, and antioxidant capabilities that can help the process of healing. Due to their excellent tissue adhesion, swelling, water absorption, bactericidal, and immune-regulating properties, polysaccharide-based bio-adhesive films have recently been investigated as intriguing alternatives in wound management. These films also mimic the structure of the skin and stimulate the regeneration of the skin. This review presented several design standards and functions of suitable bio-adhesive films for the healing of wounds. Additionally, the most recent developments in the use of bio-adhesive films as wound dressings based on polysaccharides, including hyaluronic acid, chondroitin sulfate, dextran, alginate, chitosan, cellulose, konjac glucomannan, gellan gum, xanthan gum, pectin, guar gum, heparin, arabinogalactans, carrageen, and tragacanth gum, are thoroughly discussed. Lastly, to create a road map for the function of polysaccharide-based bio-adhesive films in advanced wound care, their clinical performances and future challenges in making bio-adhesive films by three-dimensional bioprinting are summarized.
摘要：
伤口敷料作为伤口部位和外部环境之间的物理屏障，防止额外的伤害；选择合适的伤口敷料对愈合过程至关重要。近几十年来，多糖生物聚合物在伤口治疗方面表现出令人鼓舞的发现和治疗前景。此外,多糖具有抗炎等生物活性，抗菌，和抗氧化能力可以帮助愈合的过程。由于其优异的组织粘附性，肿胀,吸水,杀菌,和免疫调节特性，最近研究了基于多糖的生物粘附膜作为伤口管理中的有趣替代品。这些膜还模拟皮肤的结构并刺激皮肤的再生。这篇综述提出了几种用于伤口愈合的合适生物粘附膜的设计标准和功能。此外,使用生物粘附膜作为基于多糖的伤口敷料的最新发展，包括透明质酸,硫酸软骨素，葡聚糖,海藻酸盐,壳聚糖,纤维素,魔芋葡甘聚糖,结冷胶,黄原胶,果胶,瓜尔胶,肝素,阿拉伯半乳聚糖,角叉菜胶,和黄芪胶,进行了彻底的讨论。最后,为基于多糖的生物粘附膜在高级伤口护理中的功能创建路线图，总结了它们在通过三维生物打印制造生物粘附膜方面的临床性能和未来的挑战。
