PDF(Pubmed)
Abstract：
Clostridium difficile (C. difficile) infection (CDI) is the most common cause of healthcare-associated diarrhea and among adults, the worldwide incidence rate of the infection is increasing. There is a small amount of data in the literature for pediatric patients, but most indicate an increasing trend. C. difficile is a constituent of the normal microbiota; however, under specific conditions that cause a disruption of the normal bacterial flora, colonization of C. difficile and the released toxins that cause inflammation and mucosal damage occurs. Risk factors for CDI at any age include hospitalization, exposure to antibiotics, administration of proton pump inhibitors, invasive mechanical ventilation, immunosuppression and presence of associated comorbidities. Clinical manifestations range from asymptomatic colonization to fulminant disease characterized by toxic megacolon, intestinal perforation and, rarely, death. The aim of the present review was to outline the features of CDI in pediatric patients.
摘要：
艰难梭菌(C.艰难）感染（CDI）是医疗相关性腹泻的最常见原因，世界范围内感染的发病率正在增加。文献中有少量儿科患者的数据，但大多数都有增加的趋势.艰难梭菌是正常微生物群的组成部分；然而，在导致正常细菌菌群破坏的特定条件下，发生艰难梭菌的定植和引起炎症和粘膜损伤的释放的毒素。任何年龄的CDI的危险因素包括住院，接触抗生素，质子泵抑制剂的管理，有创机械通气，免疫抑制和相关合并症的存在。临床表现范围从无症状定植到以中毒性巨结肠为特征的暴发性疾病，肠穿孔和，很少,死亡。本综述的目的是概述儿科患者CDI的特征。
