PDF(Pubmed)
Abstract：
Cancer imposes a substantial burden and its incidence is persistently increasing in recent years. Cancer treatment has been difficult due to its inherently complex nature. The tumor microenvironment (TME) includes a complex interplay of cellular and noncellular constituents surrounding neoplastic cells, intricately contributing to the tumor initiation and progression. This critical aspect of tumors involves a complex interplay among cancer, stromal, and inflammatory cells, forming an inflammatory TME that promotes tumorigenesis across all stages. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is implicated in modulating various critical processes linked to tumor pathogenesis, including but not limited to the regulation of tumor cell proliferation, invasion, migration, and survival. Furthermore, TRAF6 prominently contributes to various immune and inflammatory pathways. The TRAF6-mediated activation of nuclear factor (NF)-κB in immune cells governs the production of proinflammatory cytokines. These cytokines sustain inflammation and stimulate tumor growth by activating NF-κB in tumor cells. In this review, we discuss various types of tumors, including gastrointestinal cancers, urogenital cancers, breast cancer, lung cancer, head and neck squamous cell carcinoma, uterine fibroids, and glioma. Employing a rigorous and systematic approach, we comprehensively evaluate the functional repertoire and potential roles of TRAF6 in various cancer types, thus highlighting TRAF6 as a compelling and emerging therapeutic target worthy of further investigation and development.
摘要：
癌症带来了巨大的负担，近年来其发病率持续增加。由于其固有的复杂性质,癌症治疗一直是困难的。肿瘤微环境（TME）包括肿瘤细胞周围的细胞和非细胞成分的复杂相互作用，复杂地促进肿瘤的启动和进展。肿瘤的这一关键方面涉及癌症之间复杂的相互作用，基质,和炎症细胞，形成炎性TME，促进所有阶段的肿瘤发生。肿瘤坏死因子受体相关因子6（TRAF6）参与调节与肿瘤发病机制相关的各种关键过程，包括但不限于肿瘤细胞增殖的调节，入侵,迁移,和生存。此外，TRAF6显著有助于各种免疫和炎症途径。TRAF6介导的免疫细胞中核因子（NF）-κB的激活控制着促炎细胞因子的产生。这些细胞因子通过激活肿瘤细胞中的NF-κB维持炎症并刺激肿瘤生长。在这次审查中,我们讨论了各种类型的肿瘤，包括胃肠道癌症，泌尿生殖系统癌症,乳腺癌,肺癌,头颈部鳞状细胞癌,子宫肌瘤,还有神经胶质瘤.采用严格和系统的方法，我们全面评估TRAF6在各种癌症类型中的功能库和潜在作用，因此强调TRAF6是一个引人注目的新兴治疗靶点，值得进一步研究和开发。
