Abstract：
Klebsiella pneumoniae is a type of Gram-negative bacteria that causes a variety of infections, including pneumonia, bloodstream infections, wound infections, and meningitis. The treatment of K. pneumoniae infection depends on the type of infection and the severity of the symptoms. Antibiotics are generally used to treat K. pneumoniae infections. However, some strains of K. pneumoniae have become resistant to antibiotics. This comprehensive review examines the potential of natural compounds as effective strategies against K. pneumonia infections. The alarming rise in antibiotic resistance underscores the urgent need for alternative therapies. This article represents current research on the effects of diverse natural compounds, highlighting their anti-microbial and antibiofilm properties against K. pneumonia. Notably, compounds such as andrographolide, artemisinin, baicalin, berberine, curcumin, epigallocatechin gallate, eugenol, mangiferin, piperine, quercetin, resveratrol, and thymol have been extensively investigated. These compounds exhibit multifaceted mechanisms, including disruption of bacterial biofilms, interference with virulence factors, and augmentation of antibiotic effectiveness. Mechanistic insights into their actions include membrane perturbation, oxidative stress induction, and altered gene expression. While promising, challenges such as limited bioavailability and varied efficacy across bacterial strains are addressed. This review further discusses the potential of natural compounds as better alternatives in combating K. pneumonia infection and emphasizes the need for continued research to harness their full therapeutic potential. As antibiotic resistance persists, these natural compounds offer a promising avenue in the fight against K. pneumonia and other multidrug-resistant pathogens.
摘要：
肺炎克雷伯菌是一种革兰氏阴性菌，可引起多种感染，包括肺炎,血流感染,伤口感染,和脑膜炎。肺炎克雷伯菌感染的治疗取决于感染类型和症状的严重程度。抗生素通常用于治疗肺炎克雷伯菌感染。然而,一些肺炎克雷伯菌菌株已对抗生素产生耐药性。这篇全面的综述研究了天然化合物作为对抗肺炎克雷伯菌感染的有效策略的潜力。抗生素耐药性的惊人上升突显了对替代疗法的迫切需求。这篇文章代表了目前对各种天然化合物的影响的研究，突出了它们对肺炎克雷伯菌的抗微生物和抗生物膜特性。值得注意的是,化合物如穿心莲内酯，青蒿素,黄芩苷,小檗碱,姜黄素,表没食子儿茶素没食子酸酯，丁香酚,芒果苷,胡椒碱,槲皮素,白藜芦醇,和百里酚已经被广泛研究。这些化合物表现出多方面的机制，包括细菌生物膜的破坏，干扰毒力因子，和增加抗生素的有效性。对它们行为的机械见解包括膜扰动，氧化应激诱导，和改变基因表达。虽然有希望，解决了诸如有限的生物利用度和跨细菌菌株的不同功效等挑战。这篇综述进一步讨论了天然化合物作为对抗肺炎克雷伯菌感染的更好替代品的潜力，并强调需要继续研究以充分利用其治疗潜力。随着抗生素耐药性的持续存在，这些天然化合物为对抗肺炎克雷伯菌和其他多药耐药病原体提供了有希望的途径。
