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Abstract：
MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with further research, evidence shows that mature miRNAs also exist in the cell nucleus, where they can impact gene transcription and ncRNA maturation in several ways. This review provides an overview of novel models of nuclear miRNA functions. Some of the models remain to be verified by experimental evidence, and more details of the miRNA regulation network remain to be discovered in the future.
摘要：
microRNAs(miRNAs)是在生理和病理过程中发挥调控作用的非编码小RNA(ncRNAs)。最初,假设miRNA仅通过诱导靶mRNA降解在细胞质中转录后调节基因表达。然而,随着进一步的研究，证据表明成熟的miRNAs也存在于细胞核中,它们可以通过多种方式影响基因转录和ncRNA成熟。本文综述了核miRNA功能的新模型。一些模型还有待实验证据验证，miRNA调控网络的更多细节仍有待发现。
