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Abstract：
BACKGROUND: To evaluate retinal structural and functional changes after silicone oil (SO) removal in eyes with macula-off rhegmatogenous retinal detachment (RRD).
METHODS: Best-corrected visual acuity (BCVA) testing, microperimetry, and optical coherence tomography angiography were performed in 48 eyes with macula-off RRD before and 3 months after SO removal. The values of healthy contralateral eyes were used as control data. Correlations between retinal vessel density (VD), retinal nerve fiber layer thickness (RNFLT), the interval between retinal detachment and surgery, the duration of SO tamponade, the follow-up time after SO removal, and visual function were analyzed.
RESULTS: Significant increases in 2˚ fixation rate (FR), 4˚ FR, 2˚ mean retinal sensitivity (MRS), 6˚ MRS, parafoveal superficial capillary plexus VD and RNFLT were observed after SO removal (all P < 0.05). The increase of 2˚ MRS and 6˚ MRS were correlated with the duration of SO tamponade and the follow-up time after SO removal respectively (all P < 0.05). The last 2˚ MRS and 6˚ MRS were correlated with the duration of SO tamponade, the interval between retinal detachment and surgery, and the follow-up time after SO removal (all P < 0.01). The last FR in RRD eyes was close to that of contralateral eyes (P > 0.05).
CONCLUSIONS: Retinal structure and function improved to different degrees after SO removal. Fixation stability and retinal sensitivity increased more than BCVA postoperatively. Retinal sensitivity, which was affected by the interval between retinal detachment and surgery and the duration of SO tamponade, gradually recovered after SO removal.
METHODS: Best-corrected visual acuity (BCVA) testing, microperimetry, and optical coherence tomography angiography were performed in 48 eyes with macula-off RRD before and 3 months after SO removal. The values of healthy contralateral eyes were used as control data. Correlations between retinal vessel density (VD), retinal nerve fiber layer thickness (RNFLT), the interval between retinal detachment and surgery, the duration of SO tamponade, the follow-up time after SO removal, and visual function were analyzed.
RESULTS: Significant increases in 2˚ fixation rate (FR), 4˚ FR, 2˚ mean retinal sensitivity (MRS), 6˚ MRS, parafoveal superficial capillary plexus VD and RNFLT were observed after SO removal (all P < 0.05). The increase of 2˚ MRS and 6˚ MRS were correlated with the duration of SO tamponade and the follow-up time after SO removal respectively (all P < 0.05). The last 2˚ MRS and 6˚ MRS were correlated with the duration of SO tamponade, the interval between retinal detachment and surgery, and the follow-up time after SO removal (all P < 0.01). The last FR in RRD eyes was close to that of contralateral eyes (P > 0.05).
CONCLUSIONS: Retinal structure and function improved to different degrees after SO removal. Fixation stability and retinal sensitivity increased more than BCVA postoperatively. Retinal sensitivity, which was affected by the interval between retinal detachment and surgery and the duration of SO tamponade, gradually recovered after SO removal.
摘要：
背景：评估硅油（SO）去除后黄斑孔源性视网膜脱离（RRD）眼的视网膜结构和功能变化。
方法：最佳矫正视力（BCVA）测试，显微视野,在去除SO之前和之后3个月，对48只眼黄斑脱落的RRD进行了光学相干断层扫描血管造影。健康对侧眼睛的值用作对照数据。视网膜血管密度（VD），视网膜神经纤维层厚度（RNFLT），视网膜脱离和手术之间的间隔,所以填塞的持续时间，去除SO后的随访时间，并对视觉功能进行了分析。
结果：固定率（FR）显着增加，4ºFR,平均视网膜敏感度（MRS），6ºMRS，SO去除后观察到了旁凹浅毛细血管丛VD和RNFLT（均P<0.05）。2ºMRS和6ºMRS的升高分别与SO填塞时间和SO去除后的随访时间相关（均P<0.05）。最后的2_MRS和6_MRS与SO填塞的持续时间相关，视网膜脱离和手术之间的间隔,去除SO后的随访时间（均P<0.01）。RRD眼末级FR接近对侧眼(P>0.05)。
结论：SO去除后视网膜结构和功能有不同程度的改善。术后固定稳定性和视网膜敏感性比BCVA增加更多。视网膜敏感性,这受到视网膜脱离和手术之间的间隔以及SO填塞持续时间的影响，去除SO后逐渐恢复。
方法：最佳矫正视力（BCVA）测试，显微视野,在去除SO之前和之后3个月，对48只眼黄斑脱落的RRD进行了光学相干断层扫描血管造影。健康对侧眼睛的值用作对照数据。视网膜血管密度（VD），视网膜神经纤维层厚度（RNFLT），视网膜脱离和手术之间的间隔,所以填塞的持续时间，去除SO后的随访时间，并对视觉功能进行了分析。
结果：固定率（FR）显着增加，4ºFR,平均视网膜敏感度（MRS），6ºMRS，SO去除后观察到了旁凹浅毛细血管丛VD和RNFLT（均P<0.05）。2ºMRS和6ºMRS的升高分别与SO填塞时间和SO去除后的随访时间相关（均P<0.05）。最后的2_MRS和6_MRS与SO填塞的持续时间相关，视网膜脱离和手术之间的间隔,去除SO后的随访时间（均P<0.01）。RRD眼末级FR接近对侧眼(P>0.05)。
结论：SO去除后视网膜结构和功能有不同程度的改善。术后固定稳定性和视网膜敏感性比BCVA增加更多。视网膜敏感性,这受到视网膜脱离和手术之间的间隔以及SO填塞持续时间的影响，去除SO后逐渐恢复。
