PDF(Pubmed)
Abstract：
Molluscum contagiosum (MC) is a skin and mucous membrane infection caused by the molluscum virus (MCV). To evaluate safety and efficacy of intralesional injection of tuberculin purified protein derivative (PPD) antigen injection versus MMR (mumps, measles, rubella) antigen for the treatment of molluscum contagiosum (MC). A total of thirty clinically confirmed patients of molluscum were recruited for this trial. Patients who were divided into three groups (A, B and C). Each group consisted of (30) patients. Group (A) subjects received intralesional MMR injections, group (B) subjects received intralesional PPD injection and group (C) received intralesional saline injection. The results of the present study revealed complete clearance of the injected lesions in 12 patients (80%), partial response in 3 patients (20%) of group (A). In group (B), complete clearance of the treated warts was observed in 11 patients (73.3%) and partial response in 4 (26.7%) of patients. In group (C), the majority of patients 8 (53.3%) demonstrated no response while 7 (46.7%) patients showed only partial clearance. We established a good safety and efficacy profile for tuberculin PPD and MMR antigens in treatment of molluscum contagiosum.
摘要：
传染性软疣（MC）是由软疣病毒（MCV）引起的皮肤和粘膜感染。评估病灶内注射结核菌素纯化蛋白衍生物（PPD）抗原注射与MMR（腮腺炎，麻疹,风疹）抗原，用于治疗传染性软疣（MC）。本试验共招募了30名临床确诊的软疣患者。患者分为三组（A，B和C）。每组由(30)名患者组成。（A）组受试者接受了病灶内MMR注射，(B)组受试者接受病灶内注射PPD,(C)组接受病灶内注射盐水。本研究的结果表明，12例患者（80％）的注射病变完全清除，部分缓解3例(20%)的组(A)。在（B）组中，11例(73.3%)患者治疗后疣完全清除,4例(26.7%)患者部分缓解.在（C）组中，大多数患者8例(53.3%)无反应,7例(46.7%)患者仅部分清除.我们建立了结核菌素PPD和MMR抗原治疗传染性软体动物的良好安全性和有效性。
