PDF(Pubmed)
Abstract：
BACKGROUND: Lophomonas blattarum is a rare protozoan that causes opportunistic infections, and the co-infection of lophomonas with tuberculosis and human hydatidosis is a serious public problem in the co-endemic areas of developing countries.
METHODS: We presented a 58-year-old female with fever, losing weight, and cough with whitish-yellow sputum that started one month ago. Increasing inflammatory markers and hypereosinophilia in laboratory tests, and a cavity with thick, regular walls and undulating air-fluid levels measuring 43 × 30, evident in the upper segment of the right lower lobe (RLL), along with consolidation and the ground glass opacity of the upper segment and posterior basal of the RLL is apparent in CT scan were reported. Then, a bronchoscopy was requested, and the BAL specimen reported a negative fungal and bacterial infection in the samples. Several live and oval flagellated lophomonas protozoa, hydatid cyst protoscoleces (the larval forms of the parasites), and M. tuberculosis were observed in microscopic evaluation. The patient was treated with metronidazole, oral albendazole, and a combination of TB regimen.
CONCLUSIONS: Physicians should always consider the possibility of co-infections of lophomonas with tuberculosis and human hydatidosis and investigate patients with risk factors such as immunodeficiency conditions or treated with immunosuppressive medications.
METHODS: We presented a 58-year-old female with fever, losing weight, and cough with whitish-yellow sputum that started one month ago. Increasing inflammatory markers and hypereosinophilia in laboratory tests, and a cavity with thick, regular walls and undulating air-fluid levels measuring 43 × 30, evident in the upper segment of the right lower lobe (RLL), along with consolidation and the ground glass opacity of the upper segment and posterior basal of the RLL is apparent in CT scan were reported. Then, a bronchoscopy was requested, and the BAL specimen reported a negative fungal and bacterial infection in the samples. Several live and oval flagellated lophomonas protozoa, hydatid cyst protoscoleces (the larval forms of the parasites), and M. tuberculosis were observed in microscopic evaluation. The patient was treated with metronidazole, oral albendazole, and a combination of TB regimen.
CONCLUSIONS: Physicians should always consider the possibility of co-infections of lophomonas with tuberculosis and human hydatidosis and investigate patients with risk factors such as immunodeficiency conditions or treated with immunosuppressive medications.
摘要：
背景：白花虫是一种罕见的原生动物，会引起机会性感染，在发展中国家的共同流行地区，环孢素与结核病和人类包虫病的共同感染是一个严重的公共问题。
方法：我们介绍了一名58岁的女性发烧，减肥,一个月前开始咳嗽发白黄色痰。在实验室测试中增加炎症标志物和嗜酸性粒细胞增多，和一个厚的空腔，规则的壁和起伏的空气-流体水平测量43×30，在右下叶（RLL）的上段明显，在CT扫描中报告了RLL的上段和后基底的固结和磨玻璃混浊。然后，要求做支气管镜检查,BAL样本报告样本中真菌和细菌感染呈阴性。几个活的和椭圆形的鞭毛单胞菌原生动物，包虫囊肿原头（寄生虫的幼虫形式），在显微镜评估中观察到结核分枝杆菌。患者接受了甲硝唑治疗,口服阿苯达唑，和结核病方案的组合。
结论：医生应始终考虑结核和人包虫病合并感染的可能性，并调查具有危险因素的患者，如免疫缺陷状况或使用免疫抑制药物治疗。
方法：我们介绍了一名58岁的女性发烧，减肥,一个月前开始咳嗽发白黄色痰。在实验室测试中增加炎症标志物和嗜酸性粒细胞增多，和一个厚的空腔，规则的壁和起伏的空气-流体水平测量43×30，在右下叶（RLL）的上段明显，在CT扫描中报告了RLL的上段和后基底的固结和磨玻璃混浊。然后，要求做支气管镜检查,BAL样本报告样本中真菌和细菌感染呈阴性。几个活的和椭圆形的鞭毛单胞菌原生动物，包虫囊肿原头（寄生虫的幼虫形式），在显微镜评估中观察到结核分枝杆菌。患者接受了甲硝唑治疗,口服阿苯达唑，和结核病方案的组合。
结论：医生应始终考虑结核和人包虫病合并感染的可能性，并调查具有危险因素的患者，如免疫缺陷状况或使用免疫抑制药物治疗。
