PDF(Pubmed)
Abstract：
Background: Brucellosis is a pervasive zoonotic disease caused by various Brucella species. It mainly affects livestock and wildlife and poses significant public health threats, especially in regions with suboptimal hygiene, food safety, and veterinary care standards. Human contractions occur by consuming contaminated animal products or interacting with infected animals. Objective: This study aims to provide an updated understanding of brucellosis, from its epidemiology and pathogenesis to diagnosis and treatment strategies. It emphasizes the importance of ongoing research, knowledge exchange, and interdisciplinary collaboration for effective disease control and prevention, highlighting its global health implications. Methods: Pathogenesis involves intricate interactions between bacteria and the host immune system, resulting in chronic infections characterized by diverse clinical manifestations. The diagnostic process is arduous owing to non-specific symptomatology and sampling challenges, necessitating a fusion of clinical and laboratory evaluations, including blood cultures, serological assays, and molecular methods. Management typically entails multiple antibiotics, although the rise in antibiotic-resistant Brucella strains poses a problem. Animal vaccination is a potential strategy to curb the spread of infection, particularly within livestock populations. Results: The study provides insights into the complex pathogenesis of brucellosis, the challenges in its diagnosis, and the management strategies involving antibiotic therapy and animal vaccination. It also highlights the emerging issue of antibiotic-resistant Brucella strains. Conclusions: In conclusion, brucellosis is a significant zoonotic disease with implications for public health. Efforts should be directed towards improved diagnostic methods, antibiotic stewardship to combat antibiotic resistance, and developing and implementing effective animal vaccination programs. Interdisciplinary collaboration and ongoing research are crucial for addressing the global health implications of brucellosis.
摘要：
背景：布鲁氏菌病是由多种布鲁氏菌引起的一种普遍的人畜共患疾病。它主要影响牲畜和野生动物，并构成重大公共卫生威胁，特别是在卫生状况欠佳的地区，食品安全,和兽医护理标准。人类收缩是通过食用受污染的动物产品或与受感染的动物相互作用而发生的。目的:本研究旨在提供布鲁氏菌病的最新认识,从流行病学和发病机制到诊断和治疗策略。它强调了持续研究的重要性，知识交流,和跨学科合作，以有效控制和预防疾病，强调其对全球健康的影响。方法：发病机制涉及细菌和宿主免疫系统之间复杂的相互作用，导致临床表现多样的慢性感染。由于非特异性症状学和抽样挑战，诊断过程是艰巨的。需要临床和实验室评估的融合，包括血培养,血清学测定，和分子方法。管理通常需要多种抗生素，尽管抗生素耐药性布鲁氏菌菌株的增加带来了一个问题。动物接种疫苗是遏制感染传播的潜在策略，特别是在牲畜种群中。结果：该研究为布鲁氏菌病的复杂发病机制提供了见解，诊断中的挑战，以及涉及抗生素治疗和动物疫苗接种的管理策略。它还强调了抗生素耐药性布鲁氏菌菌株的新兴问题。结论：总之，布鲁氏菌病是一种重要的人畜共患疾病，对公众健康有影响。应努力改进诊断方法，对抗抗生素耐药性的抗生素管理，制定和实施有效的动物疫苗接种计划。跨学科合作和正在进行的研究对于解决布鲁氏菌病的全球健康影响至关重要。
