PDF(Pubmed)
Abstract：
UNASSIGNED: Post-molar gestational trophoblastic neoplasia (pGTN) develops in about 15% to 20% of complete hydatidiform mole (CMH). Commonly, pGTN is diagnosed based on hCG monitoring following the molar evacuation. To date, no detailed information is available on how fast can pGTN develop from CHM. However, the concurrence of CHM and pGTN is extremely rare.
UNASSIGNED: A 29-year-old woman presented to the gynecology department with irregular vaginal bleeding and an elevated hCG serum level. Both ultrasound and MRI showed heterogeneous mass in uterine cavity and myometrium. Suction evacuation was performed and histologic examination of the evacuated specimen confirmed complete hydatidiform mole. Repeated ultrasound showed significant enlargement of the myometrium mass one week after the evacuation. pGTN with prognostic score of 4 was then diagnosed and multi-agent chemotherapy regimen implemented with a good prognosis.
UNASSIGNED: In rare cases, CMH can rapidly progress into pGTN. Imaging in combination with hCG surveillance seems to play a vital role guiding timely diagnosis and treatment in the specific condition. Low-risk gestational trophoblastic neoplasia (GTN) should be managed stratified according to the individual situation.
UNASSIGNED: A 29-year-old woman presented to the gynecology department with irregular vaginal bleeding and an elevated hCG serum level. Both ultrasound and MRI showed heterogeneous mass in uterine cavity and myometrium. Suction evacuation was performed and histologic examination of the evacuated specimen confirmed complete hydatidiform mole. Repeated ultrasound showed significant enlargement of the myometrium mass one week after the evacuation. pGTN with prognostic score of 4 was then diagnosed and multi-agent chemotherapy regimen implemented with a good prognosis.
UNASSIGNED: In rare cases, CMH can rapidly progress into pGTN. Imaging in combination with hCG surveillance seems to play a vital role guiding timely diagnosis and treatment in the specific condition. Low-risk gestational trophoblastic neoplasia (GTN) should be managed stratified according to the individual situation.
摘要：
■磨牙后妊娠滋养细胞瘤(pGTN)在约15%至20%的完全葡萄胎(CMH)中发展。通常,pGTN在摩尔疏散后基于hCG监测进行诊断。迄今为止,没有关于pGTN从CHM开发的速度有多快的详细信息。然而,CHM和pGTN的并发非常罕见。
■一名29岁妇女因阴道不规则出血和血清hCG水平升高而就诊于妇科。超声和MRI均显示子宫腔和子宫肌层不均匀肿块。进行抽吸排空，对排空的标本进行组织学检查，确认完全葡萄胎。重复超声检查显示，撤离后一周，子宫肌层质量明显增大。然后诊断预后评分为4分的pGTN，并实施多药化疗方案，预后良好。
■在极少数情况下，CMH可以疾速进步为pGTN。影像学检查与hCG监测相结合似乎在指导特定病情的及时诊断和治疗中起着至关重要的作用。低风险妊娠滋养细胞肿瘤（GTN）应根据个人情况进行分层处理。
■一名29岁妇女因阴道不规则出血和血清hCG水平升高而就诊于妇科。超声和MRI均显示子宫腔和子宫肌层不均匀肿块。进行抽吸排空，对排空的标本进行组织学检查，确认完全葡萄胎。重复超声检查显示，撤离后一周，子宫肌层质量明显增大。然后诊断预后评分为4分的pGTN，并实施多药化疗方案，预后良好。
■在极少数情况下，CMH可以疾速进步为pGTN。影像学检查与hCG监测相结合似乎在指导特定病情的及时诊断和治疗中起着至关重要的作用。低风险妊娠滋养细胞肿瘤（GTN）应根据个人情况进行分层处理。
