PDF(Pubmed)
Abstract：
In China, gastric cancer is the second most common cause of cancer-related death, after lung cancer. At present, the morbidity and mortality rates of gastric cancer are increasing, and targeted therapy for gastric cancer has become a research hotspot. Herein, we report a patient with multiple metastases from advanced gastric cancer. After identifying MET gene amplification, initial treatment induced regression of the tumor. However, in later stages, due to the overexpression or mutation of HER-2, KRAS, TP53, and other genes, the targeted drug therapy became ineffective, and the disease progressed rapidly, leading to the death of the patient.
摘要：
在中国,胃癌是癌症相关死亡的第二大常见原因，肺癌后。目前,胃癌的发病率和死亡率都在上升,胃癌的靶向治疗成为研究热点。在这里，我们报道了一例进展期胃癌多发转移的患者.在鉴定MET基因扩增后，初始治疗诱导肿瘤消退。然而,在后期阶段,由于HER-2，KRAS的过表达或突变，TP53和其他基因，靶向药物治疗变得无效，疾病进展迅速，导致病人死亡。
