PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the status of medication adherence and various types of risky behaviors of schizophrenia patients in a certain area of western China and to explore accordingly the correlation between the two.
UNASSIGNED: A total of 292 667 patients with schizophrenia were enrolled in a follow-up survey between 2006 and 2018. In addition, based on the outcome-wide analysis strategy, a multivariate Cox proportional risk regression model was used to estimate and compare the impact of medication adherence on different types of risky behaviors in schizophrenia patients.
UNASSIGNED: In this 13-year prospective cohort, 65 175 patients (31.4%) showed good medication adherence, while 142 394 patients (68.6%) showed poor medication adherence. The incidence rates of various risky behaviors during the follow-up period were as follows, minor nuisances, 12.25%, violation of the Law of the People\'s Republic of China on Penalties for Administration of Public Security (APS law), 3.82%, violation of criminal law, 0.94%, suicide completed, 0.28%, self-harm, 1.42%, and attempted suicide, 0.82%. Schizophrenia patients who had poor medication adherence had higher risks of committing violence against others and self-inflicted injury compared to patients with good medication adherence did, with the associated effects being minor nuisances (hazard ratio [HR]=1.31, 95% confidence interval [CI]: 1.27-1.35), violation of APS law (HR=1.47, 95% CI: 1.38-1.56), violation of criminal law (HR=1.17, 95% CI: 1.05-1.31), and self-harm (HR=1.43, 95% CI: 1.32-1.56), respectively, while the risk of suicide completed is lower in schizophrenia patients with poor medication adherence than that in patients with good medication adherence (HR=0.56, 95% CI: 0.47-0.66). There was no statistically significant association between attempted suicide and medication adherence.
UNASSIGNED: There are variations in the direction and strength of the association between medication adherence and different types of risky behaviors and further research is needed to elucidate the mechanisms of the association.
UNASSIGNED: A total of 292 667 patients with schizophrenia were enrolled in a follow-up survey between 2006 and 2018. In addition, based on the outcome-wide analysis strategy, a multivariate Cox proportional risk regression model was used to estimate and compare the impact of medication adherence on different types of risky behaviors in schizophrenia patients.
UNASSIGNED: In this 13-year prospective cohort, 65 175 patients (31.4%) showed good medication adherence, while 142 394 patients (68.6%) showed poor medication adherence. The incidence rates of various risky behaviors during the follow-up period were as follows, minor nuisances, 12.25%, violation of the Law of the People\'s Republic of China on Penalties for Administration of Public Security (APS law), 3.82%, violation of criminal law, 0.94%, suicide completed, 0.28%, self-harm, 1.42%, and attempted suicide, 0.82%. Schizophrenia patients who had poor medication adherence had higher risks of committing violence against others and self-inflicted injury compared to patients with good medication adherence did, with the associated effects being minor nuisances (hazard ratio [HR]=1.31, 95% confidence interval [CI]: 1.27-1.35), violation of APS law (HR=1.47, 95% CI: 1.38-1.56), violation of criminal law (HR=1.17, 95% CI: 1.05-1.31), and self-harm (HR=1.43, 95% CI: 1.32-1.56), respectively, while the risk of suicide completed is lower in schizophrenia patients with poor medication adherence than that in patients with good medication adherence (HR=0.56, 95% CI: 0.47-0.66). There was no statistically significant association between attempted suicide and medication adherence.
UNASSIGNED: There are variations in the direction and strength of the association between medication adherence and different types of risky behaviors and further research is needed to elucidate the mechanisms of the association.
摘要：
■调查中国西部某地区精神分裂症患者的服药依从性和各种危险行为的现状，并据此探讨两者之间的相关性。
■在2006年至2018年期间，共有292667名精神分裂症患者参加了随访调查。此外,基于结果范围分析策略，采用多变量Cox比例风险回归模型,评估和比较精神分裂症患者服药依从性对不同类型危险行为的影响.
■在这个为期13年的前瞻性队列中，65175名患者（31.4%）表现出良好的服药依从性，而142394例（68.6%）患者的服药依从性较差。随访期间各种危险行为的发生率如下,轻微的滋扰，12.25%,违反《中华人民共和国治安管理处罚法》（APS法），3.82%,触犯刑法,0.94%,自杀完成,0.28%，自我伤害,1.42%,并企图自杀,0.82%。与服药依从性良好的精神分裂症患者相比，服药依从性差的精神分裂症患者对他人实施暴力和自我伤害的风险更高。相关影响是轻微的滋扰(危险比[HR]=1.31，95%置信区间[CI]：1.27-1.35)，违反APS法(HR=1.47，95%CI：1.38-1.56)，违反刑法（HR=1.17，95%CI：1.05-1.31），和自我伤害(HR=1.43，95%CI：1.32-1.56)，分别,而服药依从性差的精神分裂症患者完成自杀的风险低于服药依从性好的患者(HR=0.56,95%CI:0.47-0.66).尝试自杀和药物依从性之间没有统计学上的显着关联。
■药物依从性与不同类型的危险行为之间的关联方向和强度存在差异，需要进一步研究以阐明关联的机制。
■在2006年至2018年期间，共有292667名精神分裂症患者参加了随访调查。此外,基于结果范围分析策略，采用多变量Cox比例风险回归模型,评估和比较精神分裂症患者服药依从性对不同类型危险行为的影响.
■在这个为期13年的前瞻性队列中，65175名患者（31.4%）表现出良好的服药依从性，而142394例（68.6%）患者的服药依从性较差。随访期间各种危险行为的发生率如下,轻微的滋扰，12.25%,违反《中华人民共和国治安管理处罚法》（APS法），3.82%,触犯刑法,0.94%,自杀完成,0.28%，自我伤害,1.42%,并企图自杀,0.82%。与服药依从性良好的精神分裂症患者相比，服药依从性差的精神分裂症患者对他人实施暴力和自我伤害的风险更高。相关影响是轻微的滋扰(危险比[HR]=1.31，95%置信区间[CI]：1.27-1.35)，违反APS法(HR=1.47，95%CI：1.38-1.56)，违反刑法（HR=1.17，95%CI：1.05-1.31），和自我伤害(HR=1.43，95%CI：1.32-1.56)，分别,而服药依从性差的精神分裂症患者完成自杀的风险低于服药依从性好的患者(HR=0.56,95%CI:0.47-0.66).尝试自杀和药物依从性之间没有统计学上的显着关联。
■药物依从性与不同类型的危险行为之间的关联方向和强度存在差异，需要进一步研究以阐明关联的机制。
